Delivering on the Promise of Purity

Delivering on the Promise of PurityTM

Tris HCL molecular structure used in buffering biologics and mRNA vaccines

TRIS HCL

Tris HCl, High Purity, Low Endotoxin, Low Metals GMP Grade

Molecular Formula

C4H12ClNO3

CAS No

1185-53-1

Molecular Weight

157.6

Solubility in Water

 560 g/L

Boiling Point

357°C

Melting Point

150°C

Quality Level

Highest – Parenteral Excipient Grade cGMP

Suitable for Injectable Biologic & Vaccine Formulations

TRIS HCl is a versatile buffering agent widely utilized in the pharmaceutical industry. This chemical compound plays a crucial role in maintaining a stable pH environment, which is vital for various biochemical and pharmaceutical processes.

TRIS HCl is a white crystalline powder that is highly soluble in water, making it easily incorporated into various pharmaceutical formulations. Its chemical structure consists of a trihydroxymethylaminomethane molecule combined with a hydrochloride group. TRIS HCl pKa is approximately 8.1 at 25°C, which makes it an effective buffer within the physiological pH range.

Pfanstiehl TRIS HCl benefits in Biologics Manufacturing:

pH Regulation

TRIS HCl pH range is 7.2 to 9.0 and is known for exceptional buffering capacity. This makes it ideal for applications where a stable pH environment is crucial, such as the manufacturing of pharmaceuticals. Maintaining the desired pH is essential for the stability and efficacy of drugs, as well as for the reproducibility of various biochemical processes.

 

Biocompatibility

TRIS HCl is considered biocompatible, meaning it is generally well-tolerated by living organisms. This characteristic is particularly important in pharmaceutical formulations intended for human use. The compatibility of TRIS HCl with biological systems makes it a preferred choice for buffering solutions in drug development.

 

Versatility

TRIS HCl is versatile and can be used in various pharmaceutical applications, including protein and enzyme purification, cell culture, and nucleic acid isolation. Its compatibility with a wide range of substances makes it a valuable buffering component for pharmaceutical manufacturers working with diverse formulations.

 

Stability

The stability of TRIS HCl, both in solid form and in solution, contributes to its reliability as a buffering agent. Pharmaceutical products often undergo extended storage periods, and the stability of the buffering system becomes crucial in maintaining the integrity of the formulation over time.

 

Minimal Interference

TRIS HCl exhibits minimal interference with biochemical and enzymatic reactions. This property is vital in ensuring that the buffering component does not negatively impact the performance of the pharmaceutical product. The low reactivity of TRIS HCl enhances its applicability in various drug development processes.

 

TRIS HCl is a valuable buffering component in the pharmaceutical industry due to its excellent pH-regulating properties, biocompatibility, versatility, stability, and minimal interference with biochemical processes.

References/Citations:

Pfanstiehl TRIS HCL Citation Page

Highest Quality for your Highest Risk Applications

Pfanstiehl’s TRIS HCL (CAS 1185-53-1) was developed specifically for biopharmaceutical formulation and commercial manufacturing and is produced under full ICH-Q7 cGMP conditions in the United States to the highest quality and purity standards.

Because of these stringent manufacturing specifications and Pfanstiehl quality systems, you can be assured that Pfanstiehl’s TRIS HCL will be of the highest quality & consistency from batch to batch and the safest available for use in your manufacturing or research application.

Product Name:

TRIS HCL (Synthetic)

Quality Level:

Highest – Compendial Parenteral Excipient Grade GMP

Attributes:

Highest Purity

Lowest Endotoxin

Lowest Metals

Lowest Bioburden

Agency Pharmacopeia:

Applications:

Parenteral Formulation

Liquid Formulation

Pharmaceutical Process

Biopharma Process

Buffer Formulation

  • Product Name:

    TRIS HCL (Synthetic)

  • Quality Level:

    Highest – Compendial Parenteral Excipient Grade GMP

  • Attributes:

    Highest Purity

    Lowest Endotoxin

    Lowest Metals

    Lowest Bioburden

  • Applications:

    Parenteral Formulation

    Liquid Formulation

    Pharmaceutical Process

    Biopharma Process

    Buffer Formulation

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