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Sodium Gluconate USP

Sodium gluconate (Molecular Formula C6H11NaO7 ) is a sodium salt of gluconic acid, which is derived from glucose through a simple fermentation process. It is a white crystalline powder that is highly soluble in water (Solubility: 590g/L at 25C). 

In pharmaceutical applications, Sodium gluconate is often used in Large Volume Parenterals (LVP) and serves various purposes:

  1. Electrolyte Agent: In Large Volume Parenterals, Sodium gluconate provides sodium ions (Naโบ), which are essential for maintaining electrolyte balance in the body. Sodium is one of the key electrolytes responsible for maintaining fluid balance, nerve function, and muscle contraction. In LVPs, it helps replenish sodium levels in the body, especially in situations where there is a deficit due to dehydration, electrolyte imbalances, or other medical conditions.

  2. Buffering Agent: Sodium gluconate can effectively act as a buffering agent due to its ability to maintain a stable pH level in parenteral pharmaceutical formulations. 
    • pH Regulation: Sodium gluconate possesses buffering capacity within a specific pH range, typically around pH 6 to 8, making it suitable for many pharmaceutical applications where this pH range is desirable.
    • pH Stability: It helps to resist changes in pH by neutralizing acidic or basic compounds that may be present in the formulation. This ensures that the pH remains within the desired range, which is crucial for maintaining the stability and efficacy of the pharmaceutical product.

  1. Compatibility: Sodium gluconate is compatible with many other pharmaceutical ingredients commonly found in Large Volume Parenteral formulations. Its compatibility ensures that the solution remains homogeneous and does not precipitate or form insoluble complexes. 

  2. Excipient: Sodium gluconate can be used as an excipient, a substance added to a pharmaceutical formulation to improve its properties. It can enhance the stability, solubility, and bioavailability of therapeutics.
Blue barrel of Pfanstiehl high purity GMP excipient grade Sodium Gluconate powder

High Purity โ€“ Low Endotoxin โ€“ Low Metals โ€“ Parenteral Grade

Pfanstiehl Brand High Purity – Low Endotoxin – Low Metal Sodium Gluconate was developed specifically for biopharmaceutical formulation and commercial manufacturing and is produced under full cGMP conditions in the United States to the highest quality and purity standards.  

Pfanstiehl Brand Sodium Gluconate is compliant with the USP monograph established in 2017 and available as USP (United States Pharmacopoeia)

Because of stringent quality systems and manufacturing specifications, you can be assured that Pfanstiehlโ€™s Sodium Gluconate will be of the highest quality & consistency from batch to batch and the safest available for use in your manufacturing or research application. 

Have questions or interested in a development sample?  

Please Click on the Contact Us below and one of our world class Technical Support Representatives will contact you.

Product DescriptionProduct CodeCAS Number
Sodium Gluconate USP (Low Endotoxin)S-108527-07-1

Available Package Sizes: 1kg, 5kg, 10kg, 25kg

Development Samples: ~100g – Available upon request