Delivering on the Promise of Purity

Delivering on the Promise of PurityTM

Tris Base Molecular Structure used in buffering biologics and vaccines

TRIS Base USP EP BP ChP

Tris Base, High Purity, Low Endotoxin, Low Metals, USP, EP, BP, ChP

Molecular Formula

C4H11NO3

CAS No

77-86-1

Molecular Weight

121.14

Solubility in Water

670 mg/mL

Boiling Point

219°C

Melting Point

167°C

Quality Level

Highest – Parenteral Excipient Grade cGMP

Suitable for Injectable Biologic & Vaccine Formulations

Tris Base is a commonly used buffer in biologics production and various biochemical and molecular biology applications. It is a zwitterionic amine, meaning it has both acidic and basic functional groups in its structure, making it an effective buffer over a wide pH range.

Pfanstiehl High Purity Low Endotoxin Tris Base benefits in biologics production:

pH Stability

TRIS Base is known for its ability to maintain a stable pH over a broad range, typically between pH 7 and 9. This is crucial in biologics production processes where maintaining a specific pH is essential for the stability and functionality of proteins.

 

Biocompatibility

TRIS Base is relatively biologically inert, which is important when working with sensitive biological molecules. It minimizes the potential for interference with biochemical reactions or interactions.

 

Water Solubility

TRIS Base is highly soluble in water, making it easy to prepare stock solutions for use in various applications. This solubility is essential in biologics production where precise and reproducible conditions are necessary.

 

Low UV Absorbance

TRIS Base exhibits low ultraviolet (UV) absorbance, which is important when working with biomolecules that are sensitive to UV light. Low absorbance helps prevent interference with spectrophotometric measurements.

 

Buffering Capacity

TRIS Base has a good buffering capacity, allowing it to resist changes in pH when small amounts of acid or base are added. This is critical in maintaining a stable environment for biologics during various stages of production.

 

Non-Toxicity

TRIS Base  is generally considered non-toxic at typical working concentrations, which is crucial for applications involving cells or proteins where cytotoxicity could be a concern.

 

Versatility

TRIS Base is versatile and can be used in a variety of applications, including electrophoresis, protein purification, enzyme assays, and other molecular biology techniques.

References/Citations:

Highest cGMP Compendial Quality for your Highest Risk Applications

Pfanstiehl Brand High Purity – Low Endotoxin – Low Metals TRIS Base

 

was developed specifically for biopharmaceutical manufacturing and is produced under full ICH-Q7 cGMP conditions in the United States to the highest quality and purity standards.

 

Pfanstiehl Brand TRIS Base is compliant with USP EP BP and ChP pharmocopoeia.

 

Because of these stringent manufacturing specifications and quality systems, you can be assured that Pfanstiehl’s Tris Base will be of the highest quality & consistency from batch to batch and the safest available for use in your manufacturing or research application.

Product Name:

TRIS Base (Synthetic)

Quality Level:

Highest – Compendial Parenteral Excipient Grade GMP

Attributes:

Highest Purity

Lowest Endotoxin

Lowest Metals

Lowest Bioburden

Agency Pharmacopeia:

USP

EP

BP

ChP

Applications:

Parenteral Formulation

Liquid Formulation

Pharmaceutical Buffering

Pharmaceutical Process

Biopharma Process

  • Product Name:

    TRIS Base (Synthetic)

  • Quality Level:

    Highest – Compendial Parenteral Excipient Grade GMP

  • Attributes:

    Highest Purity

    Lowest Endotoxin

    Lowest Metals

    Lowest Bioburden

  • Agency Pharmacopeia:

    USP

    EP

    BP

    ChP

  • Applications:

    Parenteral Formulation

    Liquid Formulation

    Pharmaceutical Buffering

    Pharmaceutical Process

    Biopharma Process

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