Trehalose Dihydrate NF EP JP ChP

Pfanstiehl Multi-Compendial Trehalose dihydrate benefits include:

Cellular Protection:
Trehalose helps protect cells and biological materials from damage caused by freezing and thawing. When cells freeze, ice crystals can form and rupture cell membranes, causing damage. Trehalose prevents ice crystal formation, keeping cell membranes intact and maintaining the structure of the cell. It also helps protect proteins and lipids inside the cells, preserving their function. This makes trehalose essential in preserving cell viability during processes like cryopreservation.

Protein Stabilization:
Trehalose dihydrate is well-known for stabilizing proteins during freezing and thawing. Proteins can become damaged or lose their shape when exposed to low temperatures, leading to problems like denaturation and clumping. Trehalose helps by forming a protective layer around proteins, keeping them stable and maintaining their proper structure. This is especially important in protein-based drugs, like vaccines, where the structure of the protein is crucial for its effectiveness.

Prevention of Freeze-Thaw Damage:
Purified, low endotoxin trehalose dihydrate is an effective cryoprotectant, reducing the harmful effects of freezing and thawing on biological materials. Freezing can cause ice crystals to form, which damage cells and proteins. Trehalose helps by preventing the formation of large ice crystals, minimizing damage. This is important in preserving biological samples, ensuring that the cells and proteins remain intact and functional.

Improved Viability and Functionality:
Trehalose dihydrate improves the survival and function of cells and biological molecules after thawing. Freezing can damage cells and reduce their effectiveness, but trehalose protects them, ensuring they retain their function when thawed. This is particularly valuable for vaccines, antibodies, and other biopharmaceutical products, where maintaining the activity of the molecules is essential for successful treatment.

Enhanced Long-Term Storage:
Trehalose dihydrate is helpful for storing biological materials at very low temperatures for long periods without losing their function. Long-term storage can cause biological products to degrade, but trehalose protects them from damage during freezing and dehydration. This is crucial in the biotechnology and pharmaceutical industries, where products need to remain stable over time for use in treatments, such as vaccines or gene therapies.