High Purity – Low Endotoxin – Low Metals

Designed for Challenging Upstream Protein Production

Tyrosine disodium dihydrate is the sodium salt form of the amino acid L-Tyrosine, containing two sodium ions and two molecules of water of crystallization. Converting L-Tyrosine into its disodium salt significantly improves its solubility in water, which is critical for use in cell culture and biopharmaceutical manufacturing.

• L-Tyrosine is a non-essential aromatic amino acid.

• In protein production, it is a required building block for recombinant proteins such as monoclonal antibodies.

• The disodium dihydrate form allows it to dissolve at practical concentrations for large-scale media preparation

Tyrosine Disodium Dihydrate is a highly soluble sodium salt form of L-tyrosine designed for use in chemically defined cell culture media and concentrated nutrient feeds for biopharmaceutical protein production.

L-Tyrosine is an essential aromatic amino acid required for cellular metabolism and recombinant protein synthesis in mammalian expression systems such as CHO cells. Because native L-tyrosine exhibits limited aqueous solubility, conversion to the disodium dihydrate form significantly enhances solubility and enables preparation of high-concentration stock solutions and feeds, supporting high-density fed-batch and perfusion processes.

In upstream manufacturing of monoclonal antibodies, recombinant proteins, and other biologics, Tyrosine Disodium Dihydrate helps sustain cell viability, optimize productivity (titer), and maintain consistent metabolic performance throughout extended culture durations.

Pfanstiehl High-purity Tyrosine Disodium Dihydrate minimizes the presence of trace metals, endotoxins, residual solvents, and oxidative or degradant impurities that can negatively impact cell growth, productivity, glycosylation profiles, charge variants, and overall product consistency. Low impurity and low bioburden levels reduce the risk of filter fouling, precipitation, and process variability, while supporting compliance with cGMP manufacturing standards and global regulatory expectations.

Pfanstiehl Pharmaceutical-grade Tyrosine Disodium Dihydrate provides manufacturers with a reliable, high-quality amino acid source that enhances upstream performance, improves batch-to-batch reproducibility, and strengthens overall control of biologics production processes.