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Sodium Succinate Hexahydrate molecular structure used for buffering vaccine and biologic solutions

Sodium Succinate (Hexahydrate)

NF JPE

Sodium Succinate (Hexahydrate), High Purity / Low Endotoxin - Low Metals, NF, JPE

Molecular Formula

C4H16Na2O10

CAS No

6106-21-4

Molecular Weight

270.14

Solubility in Water

100 mg/mL

Boiling Point

236.1°C

Melting Point

300°C

Quality Level

Highest – Parenteral Excipient Grade cGMP

Suitable for Injectable Biologic & Vaccine Formulations

Sodium Succinate hexahydrate is the sodium salt of succinic acid and commonly occurs as a hexahydrate, meaning it contains six water molecules in its crystal structure. Succinic acid is a dicarboxylic acid that is involved in various biochemical processes in the body.

In pharmaceutical manufacturing, Pfanstiehl Sodium Succinate (Hexahydrate) is used for several purposes:

Buffering Agent

Sodium succinate can act as a buffering agent, helping to maintain a stable pH in pharmaceutical formulations. This is crucial for the stability and efficacy of many drugs.

 

Stabilizer

It can be used as a stabilizing agent in certain pharmaceutical formulations, preventing degradation or decomposition of active ingredients over time. Stabilizers are essential for ensuring the quality and shelf-life of pharmaceutical products.

 

Enhanced Solubility

Sodium succinate may improve the solubility of certain drugs, making them easier to formulate and administer. This is particularly important for drugs that have poor water solubility.

 

Drug Delivery Systems

Sodium succinate hexahydrate may be incorporated into drug delivery systems, such as controlled-release formulations, to modulate the release of active ingredients over time.

 

Antioxidant Properties

Succinic acid, the parent compound of sodium succinate, has antioxidant properties. Antioxidants can help protect pharmaceutical formulations from oxidative degradation, preserving the integrity of the drugs.

 

Metabolism and Cellular Processes

Succinic acid is a naturally occurring component in the citric acid cycle, a central metabolic pathway in cells. It plays a role in energy production and various cellular processes. While the hexahydrate form may not directly impact cellular metabolism, the incorporation of succinate in pharmaceutical formulations could potentially influence certain biological processes.

References/Citations:

Pfanstiehl Sodium Succinate Citation Page

Highest cGMP Compendial Quality for your Highest Risk Applications

Pfanstiehl Brand High Purity – Low Endotoxin – Low Metals Sodium Succinate (Hexahydrate)
was developed specifically for biopharmaceutical manufacturing and is produced under full ICH-Q7 cGMP conditions in the United States to the highest quality and purity standards.

 

Pfanstiehl Brand Sodium Succinate (Hexahydrate) is compliant with NF and JPE pharmacopoeia.

 

Because of these stringent manufacturing specifications and quality systems, you can be assured that Pfanstiehl’s Sodium Succinate (Hexahydrate) will be of the highest quality & consistency from batch to batch and the safest available for use in your manufacturing or research application.

Product Name:

Sodium Succinate Hexahydrate (Plant Derived)

Quality Level:

Highest – Parenteral Excipient Grade GMP

 

Multi-Compendial Sodium Succinate (Hexahydrate)

Attributes:

Highest Purity

Lowest Endotoxin

Lowest Metals

Lowest Bioburden

Agency Pharmacopeia:

NF

JPE

Applications:

Upstream BioProcessing

Pharmaceutical Process

Biopharma Process

Pharmaceutical Final Formulation

  • Product Name:

    Sodium Succinate Hexahydrate (Plant Derived)

  • Quality Level:

    Highest – Parenteral Excipient Grade GMP

     

    Multi-Compendial Sodium Succinate (Hexahydrate)

  • Attributes:

    Highest Purity

    Lowest Endotoxin

    Lowest Metals

    Lowest Bioburden

  • Agency Pharmacopeia:

    NF

    JPE

  • Applications:

    Upstream BioProcessing

    Pharmaceutical Process

    Biopharma Process

    Pharmaceutical Final Formulation

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Available Package Sizes:

100g, 1kg, 5kg, 10kg, 25kg, and 50kg

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