{"id":4954,"date":"2024-05-21T11:35:56","date_gmt":"2024-05-21T11:35:56","guid":{"rendered":"https:\/\/pfanstiehl.com\/solutions\/formulacoes-de-alta-concentracao\/"},"modified":"2024-07-08T06:20:05","modified_gmt":"2024-07-08T06:20:05","slug":"formulacoes-de-alta-concentracao","status":"publish","type":"solutions","link":"https:\/\/pfanstiehl.com\/pt-pt\/solutions\/formulacoes-de-alta-concentracao\/","title":{"rendered":"Formula\u00e7\u00f5es de Alta Concentra\u00e7\u00e3o"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"4954\" class=\"elementor elementor-4954 elementor-456\" data-elementor-post-type=\"solutions\">\n\t\t\t\t<div class=\"elementor-element elementor-element-24f53088 e-flex e-con-boxed e-con e-parent\" data-id=\"24f53088\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-d124f80 e-flex e-con-boxed e-con e-child\" data-id=\"d124f80\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-216f275b elementor-widget elementor-widget-heading\" data-id=\"216f275b\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.23.0 - 05-08-2024 *\/\n.elementor-heading-title{padding:0;margin:0;line-height:1}.elementor-widget-heading .elementor-heading-title[class*=elementor-size-]>a{color:inherit;font-size:inherit;line-height:inherit}.elementor-widget-heading .elementor-heading-title.elementor-size-small{font-size:15px}.elementor-widget-heading .elementor-heading-title.elementor-size-medium{font-size:19px}.elementor-widget-heading .elementor-heading-title.elementor-size-large{font-size:29px}.elementor-widget-heading .elementor-heading-title.elementor-size-xl{font-size:39px}.elementor-widget-heading .elementor-heading-title.elementor-size-xxl{font-size:59px}<\/style><h1 class=\"elementor-heading-title elementor-size-default\">Solu\u00e7\u00f5es de Pfanstiehl para formula\u00e7\u00e3o de anticorpos de alta concentra\u00e7\u00e3o<\/h1>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1bd54bf2 elementor-widget elementor-widget-text-editor\" data-id=\"1bd54bf2\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.23.0 - 05-08-2024 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#69727d;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#69727d;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t<p>O desenvolvimento de formula\u00e7\u00f5es de anticorpos de alta concentra\u00e7\u00e3o (HCAF) superiores a 100mg\/ml \u00e9 essencial para a cria\u00e7\u00e3o de terapias com anticorpos monoclonais (mAb) que possam ser administradas por via subcut\u00e2nea. No entanto, a inevit\u00e1vel variabilidade entre mol\u00e9culas cria desafios t\u00e9cnicos complexos que requerem um amplo conjunto de ferramentas e conhecimentos para serem resolvidos.  <\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-263b929c e-flex e-con-boxed e-con e-child\" data-id=\"263b929c\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-45e34127 elementor-widget elementor-widget-image\" data-id=\"45e34127\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.23.0 - 05-08-2024 *\/\n.elementor-widget-image{text-align:center}.elementor-widget-image a{display:inline-block}.elementor-widget-image a img[src$=\".svg\"]{width:48px}.elementor-widget-image img{vertical-align:middle;display:inline-block}<\/style>\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"800\" height=\"491\" src=\"https:\/\/pfanstiehl.com\/wp-content\/uploads\/2024\/06\/sol-4-1024x629.png\" class=\"attachment-large size-large wp-image-2214\" alt=\"\" srcset=\"https:\/\/pfanstiehl.com\/wp-content\/uploads\/2024\/06\/sol-4-1024x629.png 1024w, https:\/\/pfanstiehl.com\/wp-content\/uploads\/2024\/06\/sol-4-300x184.png 300w, https:\/\/pfanstiehl.com\/wp-content\/uploads\/2024\/06\/sol-4-768x472.png 768w, https:\/\/pfanstiehl.com\/wp-content\/uploads\/2024\/06\/sol-4-600x368.png 600w, https:\/\/pfanstiehl.com\/wp-content\/uploads\/2024\/06\/sol-4.png 1140w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-464af55 solutions_content_box e-flex e-con-boxed e-con e-parent\" data-id=\"464af55\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-81986c7 e-flex e-con-boxed e-con e-child\" data-id=\"81986c7\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-37b8a322 elementor-widget elementor-widget-text-editor\" data-id=\"37b8a322\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h4>Desafios de viscosidade e solubilidade:<\/h4>\n<p>Um dos principais obst\u00e1culos no desenvolvimento de HCAF \u00e9 o inevit\u00e1vel aumento da viscosidade da solu\u00e7\u00e3o \u00e0 medida que a concentra\u00e7\u00e3o de mAb aumenta. Este aumento da viscosidade coloca desafios durante a filtra\u00e7\u00e3o, enchimento e outros processos de fabrica\u00e7\u00e3o. Al\u00e9m disso, solu\u00e7\u00f5es de mAb altamente concentradas podem encontrar limita\u00e7\u00f5es de solubilidade, levando \u00e0 gelifica\u00e7\u00e3o ou separa\u00e7\u00e3o de fases, especialmente em condi\u00e7\u00f5es refrigeradas. Tais ocorr\u00eancias n\u00e3o s\u00f3 comprometem a estabilidade da formula\u00e7\u00e3o, mas tamb\u00e9m amea\u00e7am a efic\u00e1cia terap\u00eautica.<\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-69a1ba89 e-flex e-con-boxed e-con e-child\" data-id=\"69a1ba89\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4f1007fa elementor-widget elementor-widget-text-editor\" data-id=\"4f1007fa\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h4>Desafios do Processo de Fabrica\u00e7\u00e3o:<\/h4>\n<p>O processo de formula\u00e7\u00e3o em si cria desafios complexos, particularmente em opera\u00e7\u00f5es unit\u00e1rias como ultrafiltra\u00e7\u00e3o-diafiltra\u00e7\u00e3o, filtra\u00e7\u00e3o est\u00e9ril e etapas de enchimento-acabamento. Esses desafios podem impedir a efici\u00eancia de fabrica\u00e7\u00e3o e aumentar os custos, exigindo solu\u00e7\u00f5es inovadoras para simplificar os processos sem comprometer a qualidade do produto.<\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-4abc820e e-flex e-con-boxed e-con e-child\" data-id=\"4abc820e\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c7ff810 elementor-widget elementor-widget-text-editor\" data-id=\"c7ff810\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h4>Preocupa\u00e7\u00f5es com a siringagem e injetabilidade:<\/h4>\n<p>A alta viscosidade e a agrega\u00e7\u00e3o de mAb n\u00e3o s\u00f3 dificultam os processos de fabrica\u00e7\u00e3o, mas tamb\u00e9m comprometem a capacidade de seringagem e injetabilidade durante o parto. Essas quest\u00f5es reduzem a ades\u00e3o do paciente e a efic\u00e1cia do tratamento, destacando a import\u00e2ncia de formula\u00e7\u00f5es otimizadas para facilitar a administra\u00e7\u00e3o.<\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-230443da e-flex e-con-boxed e-con e-child\" data-id=\"230443da\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-15829f69 elementor-widget elementor-widget-text-editor\" data-id=\"15829f69\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h4>Agrega\u00e7\u00e3o proteica e estabilidade de armazenamento:<\/h4>\n<p>A agrega\u00e7\u00e3o proteica representa um risco significativo durante o fabrico e administra\u00e7\u00e3o, o que pode levar a uma diminui\u00e7\u00e3o da pot\u00eancia terap\u00eautica. Al\u00e9m disso, a forma\u00e7\u00e3o de agregados aumenta o risco de desencadear respostas imunes antidrogas, enfatizando a necessidade de manter a estabilidade de armazenamento a longo prazo, preservando a integridade da formula\u00e7\u00e3o.<\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6a9163fc e-flex e-con-boxed e-con e-child\" data-id=\"6a9163fc\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-693d7bc elementor-widget elementor-widget-text-editor\" data-id=\"693d7bc\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h4>Excipientes e complexidade da formula\u00e7\u00e3o:<\/h4>\n<p>Os excipientes desempenham um papel fundamental na mitiga\u00e7\u00e3o da viscosidade, aumentando a solubilidade e garantindo a estabilidade nas formula\u00e7\u00f5es de HCAF. No entanto, selecionar os excipientes certos, mantendo a estabilidade da formula\u00e7\u00e3o, continua a ser uma arte misturada com a ci\u00eancia.  <\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2020c36e e-flex e-con-boxed e-con e-parent\" data-id=\"2020c36e\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1063cfe5 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"1063cfe5\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.23.0 - 05-08-2024 *\/\n.elementor-widget-divider{--divider-border-style:none;--divider-border-width:1px;--divider-color:#0c0d0e;--divider-icon-size:20px;--divider-element-spacing:10px;--divider-pattern-height:24px;--divider-pattern-size:20px;--divider-pattern-url:none;--divider-pattern-repeat:repeat-x}.elementor-widget-divider .elementor-divider{display:flex}.elementor-widget-divider .elementor-divider__text{font-size:15px;line-height:1;max-width:95%}.elementor-widget-divider .elementor-divider__element{margin:0 var(--divider-element-spacing);flex-shrink:0}.elementor-widget-divider .elementor-icon{font-size:var(--divider-icon-size)}.elementor-widget-divider .elementor-divider-separator{display:flex;margin:0;direction:ltr}.elementor-widget-divider--view-line_icon .elementor-divider-separator,.elementor-widget-divider--view-line_text .elementor-divider-separator{align-items:center}.elementor-widget-divider--view-line_icon .elementor-divider-separator:after,.elementor-widget-divider--view-line_icon .elementor-divider-separator:before,.elementor-widget-divider--view-line_text .elementor-divider-separator:after,.elementor-widget-divider--view-line_text .elementor-divider-separator:before{display:block;content:\"\";border-block-end:0;flex-grow:1;border-block-start:var(--divider-border-width) var(--divider-border-style) var(--divider-color)}.elementor-widget-divider--element-align-left .elementor-divider .elementor-divider-separator>.elementor-divider__svg:first-of-type{flex-grow:0;flex-shrink:100}.elementor-widget-divider--element-align-left .elementor-divider-separator:before{content:none}.elementor-widget-divider--element-align-left .elementor-divider__element{margin-left:0}.elementor-widget-divider--element-align-right .elementor-divider .elementor-divider-separator>.elementor-divider__svg:last-of-type{flex-grow:0;flex-shrink:100}.elementor-widget-divider--element-align-right .elementor-divider-separator:after{content:none}.elementor-widget-divider--element-align-right .elementor-divider__element{margin-right:0}.elementor-widget-divider--element-align-start .elementor-divider .elementor-divider-separator>.elementor-divider__svg:first-of-type{flex-grow:0;flex-shrink:100}.elementor-widget-divider--element-align-start .elementor-divider-separator:before{content:none}.elementor-widget-divider--element-align-start .elementor-divider__element{margin-inline-start:0}.elementor-widget-divider--element-align-end .elementor-divider .elementor-divider-separator>.elementor-divider__svg:last-of-type{flex-grow:0;flex-shrink:100}.elementor-widget-divider--element-align-end .elementor-divider-separator:after{content:none}.elementor-widget-divider--element-align-end .elementor-divider__element{margin-inline-end:0}.elementor-widget-divider:not(.elementor-widget-divider--view-line_text):not(.elementor-widget-divider--view-line_icon) .elementor-divider-separator{border-block-start:var(--divider-border-width) var(--divider-border-style) var(--divider-color)}.elementor-widget-divider--separator-type-pattern{--divider-border-style:none}.elementor-widget-divider--separator-type-pattern.elementor-widget-divider--view-line .elementor-divider-separator,.elementor-widget-divider--separator-type-pattern:not(.elementor-widget-divider--view-line) .elementor-divider-separator:after,.elementor-widget-divider--separator-type-pattern:not(.elementor-widget-divider--view-line) .elementor-divider-separator:before,.elementor-widget-divider--separator-type-pattern:not([class*=elementor-widget-divider--view]) .elementor-divider-separator{width:100%;min-height:var(--divider-pattern-height);-webkit-mask-size:var(--divider-pattern-size) 100%;mask-size:var(--divider-pattern-size) 100%;-webkit-mask-repeat:var(--divider-pattern-repeat);mask-repeat:var(--divider-pattern-repeat);background-color:var(--divider-color);-webkit-mask-image:var(--divider-pattern-url);mask-image:var(--divider-pattern-url)}.elementor-widget-divider--no-spacing{--divider-pattern-size:auto}.elementor-widget-divider--bg-round{--divider-pattern-repeat:round}.rtl .elementor-widget-divider .elementor-divider__text{direction:rtl}.e-con-inner>.elementor-widget-divider,.e-con>.elementor-widget-divider{width:var(--container-widget-width,100%);--flex-grow:var(--container-widget-flex-grow)}<\/style>\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-43a2f69 e-flex e-con-boxed e-con e-parent\" data-id=\"43a2f69\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6f3af571 elementor-widget elementor-widget-text-editor\" data-id=\"6f3af571\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h3>O que Pfanstiehl pode fazer para ajudar?<\/h3>\n<p>Os cientistas de vendas t\u00e9cnicas da Pfanstiehl podem discutir com voc\u00ea para entender seus desafios e fornecer orienta\u00e7\u00e3o com base na experi\u00eancia e revis\u00f5es da literatura para reduzir a viscosidade e estabilizar a estrutura e a atividade biol\u00f3gica de sua terap\u00eautica proteica.<\/p>\n<p>Vamos ajudar a reunir algumas ideias para:<\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-53349a58 solutions_content_box e-flex e-con-boxed e-con e-child\" data-id=\"53349a58\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-537e2e9a e-flex e-con-boxed e-con e-child\" data-id=\"537e2e9a\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-75102716 elementor-widget elementor-widget-text-editor\" data-id=\"75102716\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h4>Agentes estabilizantes:<\/h4><p>A incorpora\u00e7\u00e3o de agentes estabilizantes como a\u00e7\u00facares ou poli\u00f3is pode proteger as prote\u00ednas da desnatura\u00e7\u00e3o e agrega\u00e7\u00e3o durante o armazenamento e manuseamento.<\/p><p><a href=\"https:\/\/pfanstiehl.com\/pt-pt\/categoria-produto\/sucrose-pt-pt\/\">Pfanstiehl HPLE-LM<sup>TM<\/sup> Sacarose<\/a><br \/><a href=\"https:\/\/pfanstiehl.com\/pt-pt\/categoria-produto\/trehalose-pt-pt\/\">Pfanstiehl HPLE-LM<sup>TM<\/sup> Trehalose<\/a><br \/><a href=\"https:\/\/pfanstiehl.com\/pt-pt\/categoria-produto\/maltose-pt-pt\/\">Pfanstiehl HPLE-LM<sup>TM<\/sup> Maltose<\/a><br \/><a href=\"https:\/\/pfanstiehl.com\/pt-pt\/categoria-produto\/d-manitol-pt-pt\/\">Pfanstiehl HPLE-LM<sup>TM<\/sup> Manitol<\/a><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6cfb8826 e-flex e-con-boxed e-con e-child\" data-id=\"6cfb8826\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-50e4843d elementor-widget elementor-widget-text-editor\" data-id=\"50e4843d\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h4>Utiliza\u00e7\u00e3o de Excipientes Redutores de Viscosidade<\/h4><p>A incorpora\u00e7\u00e3o de excipientes redutores de viscosidade, como arginina, cloreto de s\u00f3dio ou amino\u00e1cidos espec\u00edficos, pode atenuar o aumento da viscosidade, mantendo a estabilidade.<\/p><p><a href=\"https:\/\/pfanstiehl.com\/pt-pt\/categoria-produto\/arginine-pt-pt\/\">Pfanstiehl HPLE-LM<sup>TM<\/sup> L-Arginina<\/a><br \/><a href=\"https:\/\/pfanstiehl.com\/pt-pt\/categoria-produto\/arginina-hcl\/\">Pfanstiehl HPLE-LM<sup>TM<\/sup> L-Arginina HCL<\/a><br \/><a href=\"https:\/\/pfanstiehl.com\/pt-pt\/categoria-produto\/histidine-pt-pt\/\">Pfanstiehl HPLE-LM<sup>TM<\/sup>\u00a0L-Histidina<\/a><br \/><a href=\"https:\/\/pfanstiehl.com\/pt-pt\/categoria-produto\/histidina-hcl-pt-pt\/\">Pfanstiehl HPLE-LM<sup>TM<\/sup> L-Histidina HCL<\/a><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-49c2453d e-flex e-con-boxed e-con e-child\" data-id=\"49c2453d\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-316d5370 elementor-widget elementor-widget-text-editor\" data-id=\"316d5370\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h4>Otimizando sistemas de buffer:<\/h4><p>Ajustar o pH e a composi\u00e7\u00e3o do sistema tamp\u00e3o pode aumentar a solubilidade e a estabilidade, cruciais para formula\u00e7\u00f5es de alta concentra\u00e7\u00e3o.<\/p><p><a href=\"https:\/\/pfanstiehl.com\/pt-pt\/categoria-produto\/tris-base-pt-pt\/\">Pfanstiehl HPLE-LM<sup>TM<\/sup> TRIS Base<\/a><br \/><a href=\"https:\/\/pfanstiehl.com\/pt-pt\/categoria-produto\/tris-hcl-pt-pt\/\">Pfanstiehl HPLE-LM<sup>TM<\/sup> Tris HCL |<\/a><br \/><a href=\"https:\/\/pfanstiehl.com\/pt-pt\/categoria-produto\/succinato-de-sodio-hexa-hidratado\/\">Pfanstiehl HPLE-LM<sup>TM<\/sup> Succinato de S\u00f3dio<\/a><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-31f233cb e-flex e-con-boxed e-con e-parent\" data-id=\"31f233cb\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2510ad33 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"2510ad33\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-128d7df3 e-flex e-con-boxed e-con e-parent\" data-id=\"128d7df3\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2a64ed02 elementor-widget elementor-widget-text-editor\" data-id=\"2a64ed02\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Por mais de 100 anos, Pfanstiehl tem feito excipientes de grau injet\u00e1vel cGMP, estabilizadores e componentes tamp\u00e3o que s\u00e3o garantidos alta pureza e baixa endotoxina. Os nossos componentes s\u00e3o utilizados na maioria dos produtos biofarmac\u00eauticos mais vendidos no mundo e continuamos a crescer todos os anos.  <\/p>\n<\/p>\n<p>Nossos clientes sabem que a combina\u00e7\u00e3o do premiado suporte t\u00e9cnico da Pfanstiehl e componentes cGMP de alta pureza e baixa endotoxina ajudar\u00e1 a garantir uma melhor consist\u00eancia de lote para lote e reduzir o risco de falha de lote de fabrica\u00e7\u00e3o para sua terap\u00eautica.<\/p>\n<\/p>\n<p>Se voc\u00ea tem uma prote\u00edna biol\u00f3gica ou vacina que requer uma formula\u00e7\u00e3o de anticorpos de alta concentra\u00e7\u00e3o (HCAF), entre em contato conosco e teremos prazer em discutir como podemos trabalhar juntos para tornar seu produto o mais alta qualidade poss\u00edvel.<\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4aa77fc elementor-widget elementor-widget-button\" data-id=\"4aa77fc\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/pfanstiehl.com\/pt-pt\/contacte-nos\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Contacte-nos<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7ecdf034 e-con-full right_fixed_btn e-flex e-con e-parent\" data-id=\"7ecdf034\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6e2be36e fixed_desktop_btn elementor-widget elementor-widget-button\" data-id=\"6e2be36e\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/pfanstiehl.com\/pt-pt\/contacte-nos\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Contacte-nos<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cd96f04 fixed_mobile_btn elementor-widget elementor-widget-button\" data-id=\"cd96f04\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/pfanstiehl.com\/pt-pt\/contacte-nos\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-far-envelope\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M464 64H48C21.49 64 0 85.49 0 112v288c0 26.51 21.49 48 48 48h416c26.51 0 48-21.49 48-48V112c0-26.51-21.49-48-48-48zm0 48v40.805c-22.422 18.259-58.168 46.651-134.587 106.49-16.841 13.247-50.201 45.072-73.413 44.701-23.208.375-56.579-31.459-73.413-44.701C106.18 199.465 70.425 171.067 48 152.805V112h416zM48 400V214.398c22.914 18.251 55.409 43.862 104.938 82.646 21.857 17.205 60.134 55.186 103.062 54.955 42.717.231 80.509-37.199 103.053-54.947 49.528-38.783 82.032-64.401 104.947-82.653V400H48z\"><\/path><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"featured_media":0,"menu_order":0,"template":"elementor_header_footer","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_uf_show_specific_survey":0,"_uf_disable_surveys":false},"class_list":["post-4954","solutions","type-solutions","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - 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No entanto, a inevit\u00e1vel variabilidade entre mol\u00e9culas cria desafios t\u00e9cnicos complexos que requerem um [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/pfanstiehl.com\/pt-pt\/solutions\/formulacoes-de-alta-concentracao\/\" \/>\n<meta property=\"og:site_name\" content=\"Pfanstiehl\" \/>\n<meta property=\"article:modified_time\" content=\"2024-07-08T06:20:05+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/pfanstiehl.com\/wp-content\/uploads\/2024\/06\/sol-4-1024x629.png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Tempo estimado de leitura\" \/>\n\t<meta name=\"twitter:data1\" content=\"4 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/pfanstiehl.com\\\/pt-pt\\\/solutions\\\/formulacoes-de-alta-concentracao\\\/\",\"url\":\"https:\\\/\\\/pfanstiehl.com\\\/pt-pt\\\/solutions\\\/formulacoes-de-alta-concentracao\\\/\",\"name\":\"Formula\u00e7\u00f5es de Alta Concentra\u00e7\u00e3o - Pfanstiehl\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/pfanstiehl.com\\\/pt-pt\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/pfanstiehl.com\\\/pt-pt\\\/solutions\\\/formulacoes-de-alta-concentracao\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/pfanstiehl.com\\\/pt-pt\\\/solutions\\\/formulacoes-de-alta-concentracao\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/pfanstiehl.com\\\/wp-content\\\/uploads\\\/2024\\\/06\\\/sol-4-1024x629.png\",\"datePublished\":\"2024-05-21T11:35:56+00:00\",\"dateModified\":\"2024-07-08T06:20:05+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/pfanstiehl.com\\\/pt-pt\\\/solutions\\\/formulacoes-de-alta-concentracao\\\/#breadcrumb\"},\"inLanguage\":\"pt-PT\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/pfanstiehl.com\\\/pt-pt\\\/solutions\\\/formulacoes-de-alta-concentracao\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"pt-PT\",\"@id\":\"https:\\\/\\\/pfanstiehl.com\\\/pt-pt\\\/solutions\\\/formulacoes-de-alta-concentracao\\\/#primaryimage\",\"url\":\"https:\\\/\\\/pfanstiehl.com\\\/wp-content\\\/uploads\\\/2024\\\/06\\\/sol-4-1024x629.png\",\"contentUrl\":\"https:\\\/\\\/pfanstiehl.com\\\/wp-content\\\/uploads\\\/2024\\\/06\\\/sol-4-1024x629.png\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/pfanstiehl.com\\\/pt-pt\\\/solutions\\\/formulacoes-de-alta-concentracao\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/pfanstiehl.com\\\/pt-pt\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Formula\u00e7\u00f5es de Alta Concentra\u00e7\u00e3o\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/pfanstiehl.com\\\/pt-pt\\\/#website\",\"url\":\"https:\\\/\\\/pfanstiehl.com\\\/pt-pt\\\/\",\"name\":\"Pfanstiehl\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\\\/\\\/pfanstiehl.com\\\/pt-pt\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/pfanstiehl.com\\\/pt-pt\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"pt-PT\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/pfanstiehl.com\\\/pt-pt\\\/#organization\",\"name\":\"Pfanstiehl\",\"url\":\"https:\\\/\\\/pfanstiehl.com\\\/pt-pt\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"pt-PT\",\"@id\":\"https:\\\/\\\/pfanstiehl.com\\\/pt-pt\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/pfanstiehl.com\\\/wp-content\\\/uploads\\\/2024\\\/06\\\/logo.png\",\"contentUrl\":\"https:\\\/\\\/pfanstiehl.com\\\/wp-content\\\/uploads\\\/2024\\\/06\\\/logo.png\",\"width\":600,\"height\":85,\"caption\":\"Pfanstiehl\"},\"image\":{\"@id\":\"https:\\\/\\\/pfanstiehl.com\\\/pt-pt\\\/#\\\/schema\\\/logo\\\/image\\\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Formula\u00e7\u00f5es de Alta Concentra\u00e7\u00e3o - Pfanstiehl","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/pfanstiehl.com\/pt-pt\/solutions\/formulacoes-de-alta-concentracao\/","og_locale":"pt_PT","og_type":"article","og_title":"Formula\u00e7\u00f5es de Alta Concentra\u00e7\u00e3o - Pfanstiehl","og_description":"Solu\u00e7\u00f5es de Pfanstiehl para formula\u00e7\u00e3o de anticorpos de alta concentra\u00e7\u00e3o O desenvolvimento de formula\u00e7\u00f5es de anticorpos de alta concentra\u00e7\u00e3o (HCAF) superiores a 100mg\/ml \u00e9 essencial para a cria\u00e7\u00e3o de terapias com anticorpos monoclonais (mAb) que possam ser administradas por via subcut\u00e2nea. 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