{"id":8866,"date":"2024-10-03T04:33:08","date_gmt":"2024-10-03T04:33:08","guid":{"rendered":"https:\/\/pfanstiehl.com\/solutions\/low-metals-%eb%b6%80%ed%98%95%ec%a0%9c\/"},"modified":"2024-10-10T19:18:31","modified_gmt":"2024-10-10T19:18:31","slug":"low-metals-%eb%b6%80%ed%98%95%ec%a0%9c","status":"publish","type":"solutions","link":"https:\/\/pfanstiehl.com\/ko\/solutions\/low-metals-%eb%b6%80%ed%98%95%ec%a0%9c\/","title":{"rendered":"Low Metals \ubd80\ud615\uc81c"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"8866\" class=\"elementor elementor-8866 elementor-8804\" data-elementor-post-type=\"solutions\">\n\t\t\t\t<div class=\"elementor-element elementor-element-47c57ccb e-flex e-con-boxed e-con e-parent\" data-id=\"47c57ccb\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-74be739a e-flex e-con-boxed e-con e-child\" data-id=\"74be739a\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-61d9515c elementor-widget elementor-widget-heading\" data-id=\"61d9515c\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.23.0 - 05-08-2024 *\/\n.elementor-heading-title{padding:0;margin:0;line-height:1}.elementor-widget-heading .elementor-heading-title[class*=elementor-size-]>a{color:inherit;font-size:inherit;line-height:inherit}.elementor-widget-heading .elementor-heading-title.elementor-size-small{font-size:15px}.elementor-widget-heading .elementor-heading-title.elementor-size-medium{font-size:19px}.elementor-widget-heading .elementor-heading-title.elementor-size-large{font-size:29px}.elementor-widget-heading .elementor-heading-title.elementor-size-xl{font-size:39px}.elementor-widget-heading .elementor-heading-title.elementor-size-xxl{font-size:59px}<\/style><h1 class=\"elementor-heading-title elementor-size-default\">\uc6d0\uc18c \ubd88\uc21c\ubb3c\uc774 \uac00\uc7a5 \ub0ae\uc740 \uc138\ud3ec \ubc30\uc591 \uc131\ubd84 \ubc0f cGMP \ube44\uacbd\uad6c \ubd80\ud615\uc81c \uc0ac\uc6a9\uc758 \uc911\uc694\uc131<\/h1>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2e42849a e-flex e-con-boxed e-con e-child\" data-id=\"2e42849a\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1480b180 elementor-widget elementor-widget-image\" data-id=\"1480b180\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.23.0 - 05-08-2024 *\/\n.elementor-widget-image{text-align:center}.elementor-widget-image a{display:inline-block}.elementor-widget-image a img[src$=\".svg\"]{width:48px}.elementor-widget-image img{vertical-align:middle;display:inline-block}<\/style>\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/pfanstiehl.com\/wp-content\/uploads\/2024\/10\/low-metals-excipients-gmp-scaled.webp\" title=\"\" alt=\"\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-4761d847 e-flex e-con-boxed e-con e-parent\" data-id=\"4761d847\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-40ed537b elementor-widget elementor-widget-text-editor\" data-id=\"40ed537b\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.23.0 - 05-08-2024 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#69727d;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#69727d;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t<p>\uce58\ub8cc\uc6a9 \uc0dd\ubb3c\ud559\uc801 \uc81c\uc81c \ubc0f \ucca8\ub2e8 \uc758\uc57d\ud488 \uc0dd\uc0b0\uc5d0\uc11c\ub294 \ucd5c\uace0 \uc218\uc900\uc758 \uc21c\ub3c4\ub97c \ubcf4\uc7a5\ud558\ub294 \uac83\uc774 \ud544\uc218\uc801\uc785\ub2c8\ub2e4. \uc0dd\ubb3c\ud559\uc801 \uc81c\uc81c \uc81c\uc870\uc5d0\uc11c \uac00\uc7a5 \uc911\uc694\ud55c \uacfc\uc81c \uc911 \ud558\ub098\ub294 \ubbf8\ub7c9 \uae08\uc18d \ubc0f \uae30\ud0c0 \ube44\ud544\uc218 \uc6d0\uc18c\uc640 \uac19\uc740 \uc6d0\uc18c \ubd88\uc21c\ubb3c\uc744 \uad00\ub9ac\ud558\ub294 \uac83\uc785\ub2c8\ub2e4. \uc774\ub7ec\ud55c \ubd88\uc21c\ubb3c\uc740 \uc5c5\uc2a4\ud2b8\ub9bc \uc138\ud3ec \ubc30\uc591 \uacf5\uc815 \ubc0f \ube44\uacbd\uad6c \uc8fc\uc0ac \uc57d\ubb3c\uc758 \ucd5c\uc885 \uc81c\ud615\uc5d0\uc11c \ubd80\uc791\uc6a9\uc744 \uc77c\uc73c\ud0ac \uc218 \uc788\uc2b5\ub2c8\ub2e4. ICH Q3D\uc640 \uac19\uc740 \uc5c4\uaca9\ud55c \uaddc\uc81c \uc9c0\uce68\uc740 \uc6d0\uc18c \ubd88\uc21c\ubb3c\uc758 \ud5c8\uc6a9 \uc218\uc900\uc744 \uad00\ub9ac\ud558\ubbc0\ub85c \uc774\ub7ec\ud55c \uc81c\uc5b4\ub294 \uc81c\ud488 \uc548\uc804\uc131\uacfc \ud6a8\ub2a5\uc5d0 \ub9e4\uc6b0 \uc911\uc694\ud569\ub2c8\ub2e4.   <\/p>\n<\/p>\n<p>Pfanstiehl\uc740 \uc6d0\uc18c \ubd88\uc21c\ubb3c\uc744 \ud604\uc800\ud788 \uc904\uc774\ub294 \ub3c5\uc810 \uacf5\uc815\uc744 \ud65c\uc6a9\ud558\uc5ec \uc774 \ubb38\uc81c\ub97c \ud574\uacb0\ud558\uba70, \uc774\ub294 \ud604\uc7ac \uc0b0\uc5c5 \ud45c\uc900\ubcf4\ub2e4 100\ubc30\uc5d0\uc11c 1000\ubc30 \uc801\uc740 \ud55c \uc790\ub9bf\uc218 ppb(parts per billion) \uc218\uc900\uae4c\uc9c0 \uac10\uc18c\uc2dc\ud0b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \ud0c1\uc6d4\ud55c \uc21c\ub3c4\ub294 \uc6d0\uc18c \ubd88\uc21c\ubb3c\uacfc \uad00\ub828\ub41c \uc704\ud5d8\uc744 \uc644\ud654\ud558\ub294 \ub370 \ub3c4\uc6c0\uc774 \ub418\uba70, \uc5c4\uaca9\ud55c \uaddc\uc81c \uc694\uad6c \uc0ac\ud56d\uc744 \ucda9\uc871\ud558\ub294 \uace0\ud488\uc9c8 \uce58\ub8cc\uc6a9 \uc0dd\ubb3c\ud559\uc801 \uc81c\uc81c\ub97c \ubcf4\uc7a5\ud569\ub2c8\ub2e4. <\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1a76f76c elementor-widget elementor-widget-text-editor\" data-id=\"1a76f76c\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h3>1. \uc138\ud3ec \ubc30\uc591 \ubc0f \uc5c5\uc2a4\ud2b8\ub9bc \uacf5\uc815\uc5d0\uc11c \uc6d0\uc18c \ubd88\uc21c\ubb3c\uc758 \uc704\ud5d8<\/h3>\n<p>\uce58\ub8cc\uc6a9 \uc0dd\ubb3c\ud559\uc801 \uc81c\uc81c\uc5d0\uc11c \uc138\ud3ec \ubc30\uc591 \uc2dc\uc2a4\ud15c\uc740 \ubcf5\uc7a1\ud55c \ub2e8\ubc31\uc9c8\uc744 \uc0dd\uc0b0\ud558\ub294 \ub370 \uc0ac\uc6a9\ub429\ub2c8\ub2e4. \ubbf8\ub7c9\uc758 \uc6d0\uc18c \ubd88\uc21c\ubb3c\uc774 \uc874\uc7ac\ud558\uba74 \ucd5c\uc801\uc758 \ub2e8\ubc31\uc9c8 \uc0dd\uc0b0\uc5d0 \ud544\uc694\ud55c \uc12c\uc138\ud55c \uade0\ud615\uc744 \uae68\ub728\ub9b4 \uc218 \uc788\uc2b5\ub2c8\ub2e4. Pfanstiehl\uc758 \ub3c5\uc810\uc801\uc778 \uacf5\uc815\uc740 \uc138\ud3ec \ubc30\uc591 \uc131\ubd84\uc5d0 \uc774\ub7ec\ud55c \ubd88\uc21c\ubb3c\uc758 \ub18d\ub3c4\uac00 \ud06c\uac8c \uac10\uc18c\ud558\ub3c4\ub85d \ubcf4\uc7a5\ud558\uba70, \uc774\ub294 \uba87 \uac00\uc9c0 \uc911\uc694\ud55c \uc774\uc810\uc73c\ub85c \uc774\uc5b4\uc9d1\ub2c8\ub2e4.  <\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cb6e00c elementor-widget elementor-widget-text-editor\" data-id=\"cb6e00c\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h4>a) \uc138\ud3ec \ub3c5\uc131\uc758 \uc644\ud654<\/h4>\n\ub0a9, \uc218\uc740, \uce74\ub4dc\ubbb4 \ubc0f \ube44\uc18c\uc640 \uac19\uc740 \uc6d0\uc18c \ubd88\uc21c\ubb3c\uc740 \ub9e4\uc6b0 \ub0ae\uc740 \ub18d\ub3c4\uc5d0\uc11c\ub3c4 \uc138\ud3ec\uc5d0 \ub9e4\uc6b0 \ub3c5\uc131\uc774 \uc788\uc2b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \ubd88\uc21c\ubb3c\ub85c \uc778\ud55c \ub3c5\uc131\uc740 \uc138\ud3ec \uc0dd\uc874\ub825\uc744 \uac10\uc18c\uc2dc\ud0a4\uace0 \ub2e8\ubc31\uc9c8 \uc0dd\uc131\uc744 \uc190\uc0c1\uc2dc\ud0ac \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc6d0\uc18c \ubd88\uc21c\ubb3c\uc744 \uc885\uc885 \ud55c \uc790\ub9bf\uc218 ppb\ub85c \uce21\uc815\ub418\ub294 \uc218\uc900\uc73c\ub85c \uc904\uc774\ub294 Pfanstiehl\uc758 \ub2a5\ub825\uc740 \uc774\ub7ec\ud55c \ub3c5\uc131\uc744 \ucd5c\uc18c\ud654\ud558\uc5ec \ub354 \uac74\uac15\ud55c \uc138\ud3ec \ubc30\uc591\uacfc \ub354 \uac15\ub825\ud55c \ub2e8\ubc31\uc9c8 \uc218\uc728\uc744 \uc5bb\ub294 \ub370 \ub3c4\uc6c0\uc774 \ub429\ub2c8\ub2e4.  \t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ce2aa29 elementor-widget elementor-widget-text-editor\" data-id=\"ce2aa29\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h4>b) \ud6a8\uc18c \uc5b5\uc81c \uc608\ubc29<\/h4>\n<p>\ud6a8\uc18c \ubc18\uc751\uc740 \uc0dd\ubb3c\ud559\uc801 \uc0dd\uc0b0\uc5d0 \ud544\uc218\uc801\uc774\uba70, \ub2e8\ubc31\uc9c8 \ud569\uc131\uc744 \ucd09\uc9c4\ud558\uace0 \ud544\uc694\ud55c \ubc88\uc5ed \ud6c4 \ubcc0\ud615\uc744 \ucd09\uc9c4\ud569\ub2c8\ub2e4. \uad6c\ub9ac \ubc0f \uc544\uc5f0\uacfc \uac19\uc740 \uc6d0\uc18c \ubd88\uc21c\ubb3c\uc740 \ud65c\uc131 \ubd80\uc704\uc5d0 \uacb0\ud569\ud558\uac70\ub098 \uad6c\uc870\ub97c \ubcc0\uacbd\ud558\uc5ec \ud6a8\uc18c\ub97c \uc5b5\uc81c\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. Pfanstiehl\uc740 \uc774\ub7ec\ud55c \ubd88\uc21c\ubb3c\uc744 \uc5c5\uacc4 \ud45c\uc900\ubcf4\ub2e4 \ud6e8\uc52c \ub0ae\uc740 \uc218\uc900\uc73c\ub85c \ub0ae\ucda4\uc73c\ub85c\uc368 \ud6a8\uc18c \uae30\ub2a5\uc744 \uc720\uc9c0\ud558\ub294 \ub370 \ub3c4\uc6c0\uc774 \ub418\uba70, \uc774\ub294 \ub2e8\ubc31\uc9c8 \ud569\uc131 \ubc0f \uce58\ub8cc\uc6a9 \ub2e8\ubc31\uc9c8\uc758 \ud6a8\ub2a5\uc5d0 \uc911\uc694\ud55c \ub2f9\ud654(glycosylation)\uc640 \uac19\uc740 \ubc88\uc5ed \ud6c4 \ucda9\uc2e4\ub3c4\ub97c \ud5a5\uc0c1\uc2dc\ud0b5\ub2c8\ub2e4.  <\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-01d5a3f elementor-widget elementor-widget-text-editor\" data-id=\"01d5a3f\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h4>c) \ub2f9\ud654(glycosylation) \ud328\ud134\uc758 \ud30c\uad34<\/h4>\n<p>\uc801\uc808\ud55c \uae00\ub9ac\ucf54\uc2e4\ud654(glycosylation)\ub294 \uce58\ub8cc\uc6a9 \ub2e8\ubc31\uc9c8\uc758 \uc548\uc815\uc131, \ud6a8\ub2a5 \ubc0f \uc0dd\ubb3c\ud559\uc801 \ud65c\uc131\uc5d0 \ub9e4\uc6b0 \uc911\uc694\ud569\ub2c8\ub2e4. \uc544\uc5f0 \ubc0f \uad6c\ub9ac\uc640 \uac19\uc740 \ubbf8\ub7c9 \uae08\uc18d\uc740 \ub2e8\ubc31\uc9c8\uc5d0 \ud0c4\uc218\ud654\ubb3c \uadf8\ub8f9\uc744 \ucd94\uac00\ud558\ub294 \ud6a8\uc18c\ub97c \ubc29\ud574\ud558\uc5ec \ub2f9\ud654(glycosylation) \uacfc\uc815\uc5d0 \ud63c\ub780\uc744 \uc77c\uc73c\ud0ac \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \ud30c\uad34\ub294 \uae00\ub9ac\ucf54\uc2e4\ud654(glycosylation) \ud328\ud134\uc744 \ubcc0\ud654\uc2dc\ucf1c \ub2e8\ubc31\uc9c8\uc774 \ubd80\uc801\uc808\ud558\uac8c \uc811\ud788\uace0, \uc548\uc815\uc131\uc774 \ub5a8\uc5b4\uc9c0\uba70, \uc7a0\uc7ac\uc801\uc73c\ub85c \ub354 \uba74\uc5ed\uc6d0\uc131\uc73c\ub85c \uc774\uc5b4\uc9c8 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc774\ub294 \uc0dd\ubb3c\ud559\uc801 \uc81c\uc81c\uc758 \uce58\ub8cc \ud6a8\ub2a5\uc5d0 \uc2ec\uac01\ud55c \uc601\ud5a5\uc744 \ubbf8\uce60 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc6d0\uc18c \ubd88\uc21c\ubb3c\uc774 \ub9e4\uc6b0 \ub0ae\uc740 \uc138\ud3ec \ubc30\uc591 \uc131\ubd84\uc744 \uc0ac\uc6a9\ud568\uc73c\ub85c\uc368 Pfanstiehl\uc740 \ub2f9\ud654(glycosylation) \ud328\ud134\uc774 \uc77c\uad00\ub418\uace0 \uc815\ud655\ud558\uac8c \uc720\uc9c0\ub418\ub3c4\ub85d \ud558\uc5ec \uace0\ud488\uc9c8\uc758 \ud6a8\uacfc\uc801\uc778 \uc0dd\ubb3c\ud559\uc801 \uc81c\uc81c \uc0dd\uc0b0\uc5d0 \uae30\uc5ec\ud569\ub2c8\ub2e4.    <\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7b79943 elementor-widget elementor-widget-text-editor\" data-id=\"7b79943\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h4>d) \ub2e8\ubc31\uc9c8 \uc751\uc9d1\uc758 \uac10\uc18c<\/h4>\n<p>\uc6d0\uc18c \ubd88\uc21c\ubb3c\uc740 \ub610\ud55c \ub2e8\ubc31\uc9c8 \uc624\uc811\ud798 \ubc0f \uc751\uc9d1\uc5d0 \uae30\uc5ec\ud560 \uc218 \uc788\uc73c\uba70, \uc774\ub294 \uc0dd\ubb3c\ud559\uc801 \uc81c\uc81c\uc758 \uc804\ubc18\uc801\uc778 \ud488\uc9c8\uc744 \uc190\uc0c1\uc2dc\ud0b5\ub2c8\ub2e4. \ub2e8\ubc31\uc9c8 \uc751\uc9d1\uc740 \uae30\ub2a5\uc131 \ub2e8\ubc31\uc9c8\uc758 \uc218\uc728\uc744 \ub0ae\ucd94\uace0 \uba74\uc5ed\uc6d0\uc131\uc758 \uc704\ud5d8\uc744 \uc99d\uac00\uc2dc\ud0ac \uc218 \uc788\uae30 \ub54c\ubb38\uc5d0 \ud2b9\ud788 \uc6b0\ub824\ub429\ub2c8\ub2e4. Pfanstiehl\uc758 \uc131\ubd84\uc740 \ubd88\uc21c\ubb3c \ud568\ub7c9\uc774 \ub9e4\uc6b0 \ub0ae\uae30 \ub54c\ubb38\uc5d0 \uc751\uc9d1 \uc704\ud5d8\uc744 \ucd5c\uc18c\ud654\ud558\uc5ec \uc0dd\ubb3c\ud559\uc801\uc73c\ub85c \ud65c\uc131\ud654\ub418\uace0 \uc801\uc808\ud558\uac8c \uc811\ud78c \ub2e8\ubc31\uc9c8\uc758 \uc218\uc728\uc744 \ub192\uc77c \uc218 \uc788\uc2b5\ub2c8\ub2e4.  <\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-15b75d0 elementor-widget elementor-widget-text-editor\" data-id=\"15b75d0\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h3>2. \uc6d0\uc18c \ubd88\uc21c\ubb3c\uc774 \uac00\uc7a5 \ub0ae\uc740 cGMP \ube44\uacbd\uad6c \ubd80\ud615\uc81c\uc758 \uc911\uc694\uc131<\/h3>\n<p>\ube44\uacbd\uad6c \uc0dd\ubb3c\ud559\uc801 \uc81c\uc81c\uc5d0\uc11c\ub294 \ucd5c\uc885 \uc81c\ud615\uc774 \ud658\uc790\uc5d0\uac8c \uc9c1\uc811 \ud22c\uc5ec\ub418\ubbc0\ub85c \ubd80\ud615\uc81c\uc758 \uc21c\ub3c4\ub294 \uc57d\ubb3c\uc758 \uc548\uc804\uc131\uacfc \ud6a8\ub2a5\uc5d0 \ub9e4\uc6b0 \uc911\uc694\ud569\ub2c8\ub2e4. \uadf9\uc18c\ub7c9\uc758 \uc6d0\uc18c \ubd88\uc21c\ubb3c\uc870\ucc28\ub3c4 \uce58\ub8cc\uc6a9 \ub2e8\ubc31\uc9c8\uc744 \ubd84\ud574\ud558\uac70\ub098, \uba74\uc5ed \ubd80\uc791\uc6a9\uc758 \uc704\ud5d8\uc744 \uc99d\uac00\uc2dc\ud0a4\uac70\ub098, \uc57d\ubb3c \uc548\uc815\uc131\uc744 \uac10\uc18c\uc2dc\ud0ac \uc218 \uc788\uc2b5\ub2c8\ub2e4. Pfanstiehl\uc758 \ub3c5\uc810\uc801\uc778 \uacf5\uc815\uc740 cGMP \ube44\uacbd\uad6c \ubd80\ud615\uc81c\uc5d0 \uc57d\ubb3c \uc548\uc804\uc131 \ubc0f \uc131\ub2a5\uc5d0 \uc0c1\ub2f9\ud55c \uc601\ud5a5\uc744 \ubbf8\uce58\ub294 \uc5c5\uacc4 \ud45c\uc900\ubcf4\ub2e4 \ud6e8\uc52c \ub0ae\uc740 \uc218\uc900\uc758 \uc6d0\uc18c \ubd88\uc21c\ubb3c\uc774 \ud3ec\ud568\ub418\ub3c4\ub85d \ubcf4\uc7a5\ud569\ub2c8\ub2e4.  <\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-69d3c4d elementor-widget elementor-widget-text-editor\" data-id=\"69d3c4d\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h4>a) \uc57d\ubb3c \uc548\uc815\uc131 \ud5a5\uc0c1<\/h4>\n<p>\uc6d0\uc18c \ubd88\uc21c\ubb3c, \ud2b9\ud788 \ucca0\uacfc \uac19\uc740 \uae08\uc18d\uc740 \ub2e8\ubc31\uc9c8\uc744 \ubd84\ud574\ud558\ub294 \uc0b0\ud654 \ubc18\uc751\uc744 \ucd09\uc9c4\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \ubd84\ud574\ub294 \uc57d\ubb3c\uc758 \uc548\uc815\uc131, \ud6a8\ub2a5 \ubc0f \uc720\ud1b5 \uae30\ud55c\uc744 \uac10\uc18c\uc2dc\ud0b5\ub2c8\ub2e4. \ud55c \uc790\ub9bf\uc218 ppb \ubd88\uc21c\ubb3c \uc218\uc900\uc744 \ub2ec\uc131\ud558\ub294 Pfanstiehl\uc758 \ubd80\ud615\uc81c\ub294 \uc774\ub7ec\ud55c \ucd09\ub9e4 \ubc18\uc751\uc758 \uac00\ub2a5\uc131\uc744 \ucd5c\uc18c\ud654\ud558\uc5ec \ubcf4\ub2e4 \uc548\uc815\uc801\uc774\uace0 \uc624\ub798 \uc9c0\uc18d\ub418\ub294 \uce58\ub8cc \uc81c\ud488\uc744 \ubcf4\uc7a5\ud569\ub2c8\ub2e4.  <\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5226cf4 elementor-widget elementor-widget-text-editor\" data-id=\"5226cf4\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h4>b) \uba74\uc5ed\uc6d0\uc131 \uc704\ud5d8 \uac10\uc18c<\/h4>\n<p>\uc6d0\uc18c \ubd88\uc21c\ubb3c\ub85c \uc778\ud574 \ub2e8\ubc31\uc9c8\uc774 \ubd84\ud574\ub418\uac70\ub098 \uc751\uc9d1\ub418\uba74 \ud658\uc790\uc758 \uba74\uc5ed \ubc18\uc751\uc744 \uc720\ubc1c\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uba74\uc5ed\uc6d0\uc131\uc740 \ud6a8\ub2a5\uc744 \uac10\uc18c\uc2dc\ud0a4\uace0 \ud56d\uc57d\ubb3c \ud56d\uccb4(ADA) \uac1c\ubc1c\uc744 \ud3ec\ud568\ud55c \uba74\uc5ed \ubd80\uc791\uc6a9\uc744 \uc720\ubc1c\ud560 \uc218 \uc788\uae30 \ub54c\ubb38\uc5d0 \uc0dd\ubb3c\ud559\uc801 \uc758\uc57d\ud488\uc758 \uc8fc\uc694 \uad00\uc2ec\uc0ac\uc785\ub2c8\ub2e4. Pfanstiehl\uc758 \ubd80\ud615\uc81c\ub294 \ubd88\uc21c\ubb3c\uc744 \ud604\uc7ac \uc0b0\uc5c5 \ud45c\uc900\ubcf4\ub2e4 100\ubc30\uc5d0\uc11c 1000\ubc30 \ub0ae\uc740 \uc218\uc900\uc73c\ub85c \uc904\uc784\uc73c\ub85c\uc368 \uba74\uc5ed\uc6d0\uc131\uc758 \uc704\ud5d8\uc744 \ud06c\uac8c \ub0ae\ucd94\uc5b4 \ubcf4\ub2e4 \uc548\uc804\ud558\uace0 \ud6a8\uacfc\uc801\uc778 \uce58\ub8cc \uc81c\ud488\uc5d0 \uae30\uc5ec\ud569\ub2c8\ub2e4.  <\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-34c2abe elementor-widget elementor-widget-text-editor\" data-id=\"34c2abe\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h4>c) \ud658\uc790 \uc548\uc804 \uac1c\uc120<\/h4>\n<p>\ub0a9, \uc218\uc740 \ubc0f \ube44\uc18c\uc640 \uac19\uc740 \uc6d0\uc18c \ubd88\uc21c\ubb3c\uc740 \ubbf8\ub7c9\uc774\ub77c\ub3c4 \ud608\ub958\uc5d0 \uc720\uc785\ub420 \ub54c \ub9e4\uc6b0 \ub3c5\uc131\uc774 \uc788\uc2b5\ub2c8\ub2e4. Pfanstiehl\uc758 \ub3c5\uc810\uc801\uc778 \uacf5\uc815\uc740 \ubd80\ud615\uc81c\uc5d0 \ucd5c\uc18c\ud55c\uc758 \ub3c5\uc131 \uc694\uc18c\uac00 \ud3ec\ud568\ub418\uc5b4 \uc804\uc2e0 \ub3c5\uc131, \uc7a5\uae30 \uc190\uc0c1 \ubc0f \uc774\ub7ec\ud55c \uc624\uc5fc \ubb3c\uc9c8\uacfc \uad00\ub828\ub41c \uae30\ud0c0 \ubd80\uc791\uc6a9\uc744 \ubc29\uc9c0\ud558\uc5ec \ud658\uc790 \uc548\uc804\uc744 \ud06c\uac8c \ud5a5\uc0c1\uc2dc\ud0b5\ub2c8\ub2e4. <\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0dd23fc elementor-widget elementor-widget-text-editor\" data-id=\"0dd23fc\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h4>d) \uaddc\uc815 \uc900\uc218<\/h4>\nPfanstiehl\uc758 \ubd80\ud615\uc81c\ub294 \uc6d0\uc18c \ubd88\uc21c\ubb3c\uc5d0 \ub300\ud55c ICH Q3D \ud45c\uc900\uc744 \ud3ec\ud568\ud55c \uaddc\uc81c \uc9c0\uce68\uc744 \ucda9\uc871\ud560 \ubfd0\ub9cc \uc544\ub2c8\ub77c \uc774\ub97c \ub2a5\uac00\ud558\ub294 \uacbd\uc6b0\uac00 \ub9ce\uc2b5\ub2c8\ub2e4. \uc5c5\uacc4 \ud45c\uc900\ubcf4\ub2e4 \ud6e8\uc52c \ub0ae\uc740 \ubd88\uc21c\ubb3c \uc218\uc900\uc744 \ub2ec\uc131\ud558\uba74 \uc81c\uc870\uc5c5\uccb4\uac00 \uae00\ub85c\ubc8c \uaddc\uc81c \uc694\uad6c \uc0ac\ud56d\uc744 \ubcf4\ub2e4 \uc27d\uace0 \uc790\uc2e0 \uc788\uac8c \uc900\uc218\ud560 \uc218 \uc788\uc73c\ubbc0\ub85c \uaddc\uc81c \uae30\uad00\uc758 \ube44\uc6a9\uc774 \ub9ce\uc774 \ub4dc\ub294 \uc9c0\uc5f0, \ub9ac\ucf5c \ub610\ub294 \uac70\ubd80\ub97c \ubc29\uc9c0\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a34fcac e-flex e-con-boxed e-con e-parent\" data-id=\"a34fcac\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-29022c3 elementor-widget elementor-widget-text-editor\" data-id=\"29022c3\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h3>\ub0ae\uc740 \uc6d0\uc18c \ubd88\uc21c\ubb3c\uc744 \uc704\ud55c Pfanstiehl\uc758 \ub3c5\uc810 \uacf5\uc815: \ud55c \uc790\ub9bf\uc218 ppb<\/h3>\n<p>Pfanstiehl\uc758 \uc5c5\uacc4 \ucd5c\uace0\uc758 \ub3c5\uc810 \uacf5\uc815\uc744 \ud1b5\ud574 \ub9e4\uc6b0 \ub0ae\uc740 \uc218\uc900\uc758 \uc6d0\uc18c \ubd88\uc21c\ubb3c\ub85c \uc138\ud3ec \ubc30\uc591 \uc131\ubd84 \ubc0f cGMP \ube44\uacbd\uad6c \ubd80\ud615\uc81c\ub97c \uc0dd\uc0b0\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ubd88\uc21c\ubb3c\uc744 \uae30\uc874 \uc0b0\uc5c5 \ud45c\uc900\ubcf4\ub2e4 -100\ubc30\uc5d0\uc11c 1000\ubc30 \ub0ae\uc740 \ud55c \uc790\ub9bf\uc218 ppb \uc218\uc900\uc73c\ub85c \uc904\uc784\uc73c\ub85c\uc368 Pfanstiehl\uc758 \uc81c\ud488\uc740 \uce58\ub8cc\uc6a9 \uc0dd\ubb3c\ud559\uc801 \uc81c\uc81c \uc0dd\uc0b0\uc5d0\uc11c \uc21c\ub3c4\uc5d0 \ub300\ud55c \uc0c8\ub85c\uc6b4 \uae30\uc900\uc744 \uc81c\uacf5\ud569\ub2c8\ub2e4. \uc774\ub7ec\ud55c \ub9e4\uc6b0 \ub0ae\uc740 \uc218\uc900\uc758 \ubd88\uc21c\ubb3c\uc740 \ub2e4\uc74c\uacfc \uac19\uc740 \uc5ec\ub7ec \uac00\uc9c0 \uc911\uc694\ud55c \uc774\uc810\uc744 \uc81c\uacf5\ud569\ub2c8\ub2e4.  <\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a03233a elementor-widget elementor-widget-text-editor\" data-id=\"a03233a\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul>\n<li><strong>\ub354 \ub192\uc740 \ub2e8\ubc31\uc9c8 \uc218\uc728:<\/strong> \uc138\ud3ec \ubc30\uc591 \uc131\ubd84\uc758 \ubd88\uc21c\ubb3c\uc774 \uc801\uc73c\uba74 \uc138\ud3ec\uac00 \ub354 \uac74\uac15\ud574\uc9c0\uace0 \uc0b0\ud654 \uc2a4\ud2b8\ub808\uc2a4\uac00 \uac10\uc18c\ud558\uba70 \uc0dd\ubb3c\ud559\uc801 \ud65c\uc131 \ub2e8\ubc31\uc9c8\uc758 \uc218\uc728\uc774 \ub192\uc544\uc9d1\ub2c8\ub2e4.<\/li>\n<li><strong>\uc77c\uad00\uc131 \ubc0f \ud488\uc9c8 \ud5a5\uc0c1:<\/strong> \uc6d0\uc18c \ubd88\uc21c\ubb3c\uc758 \uac10\uc18c\ub294 \ubcf4\ub2e4 \uc77c\uad00\ub41c \uc81c\ud488 \ud488\uc9c8\uc744 \ubcf4\uc7a5\ud558\uc5ec \ubc30\uce58 \uac04 \ubcc0\ub3d9\uc131\uc744 \uc904\uc774\uace0 \ub354 \ub192\uc740 \uc218\uc900\uc758 \uaddc\uc815 \uc900\uc218\ub97c \ubcf4\uc7a5\ud569\ub2c8\ub2e4.<\/li>\n<li><strong>\ucd5c\uc885 \uc81c\ud615\uc5d0\uc11c \ucd5c\uc18c\ud654\ub41c \uc704\ud5d8:<\/strong> \uc81c\uc870\uc5c5\uccb4\ub294 \ubd88\uc21c\ubb3c\uc774 \ucd5c\uc18c\ud654\ub41c \ubd80\ud615\uc81c\ub97c \uc0ac\uc6a9\ud568\uc73c\ub85c\uc368 \ucd5c\uc885 \uc758\uc57d\ud488\uc5d0\uc11c \ub2e8\ubc31\uc9c8 \ubd84\ud574, \uc751\uc9d1 \ub610\ub294 \uba74\uc5ed\uc6d0\uc131\uc758 \uac00\ub2a5\uc131\uc744 \uc904\uc5ec \uc804\ubc18\uc801\uc778 \uce58\ub8cc \ud6a8\ub2a5\uacfc \uc548\uc804\uc131\uc744 \uac1c\uc120\ud560 \uc218 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