{"id":5018,"date":"2024-05-21T11:01:18","date_gmt":"2024-05-21T11:01:18","guid":{"rendered":"https:\/\/pfanstiehl.com\/solutions\/riduzione-dellaggregazione-proteica\/"},"modified":"2026-11-05T23:31:13","modified_gmt":"2026-11-05T23:31:13","slug":"riduzione-dellaggregazione-proteica","status":"publish","type":"solutions","link":"https:\/\/pfanstiehl.com\/it\/solutions\/riduzione-dellaggregazione-proteica\/","title":{"rendered":"Riduzione dell&#8217;aggregazione proteica"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"5018\" class=\"elementor elementor-5018 elementor-372\" data-elementor-post-type=\"solutions\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4553736b e-flex e-con-boxed e-con e-parent\" data-id=\"4553736b\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-37688f53 e-flex e-con-boxed e-con e-child\" data-id=\"37688f53\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1769ebe9 elementor-widget elementor-widget-heading\" data-id=\"1769ebe9\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.23.0 - 05-08-2024 *\/\n.elementor-heading-title{padding:0;margin:0;line-height:1}.elementor-widget-heading .elementor-heading-title[class*=elementor-size-]>a{color:inherit;font-size:inherit;line-height:inherit}.elementor-widget-heading .elementor-heading-title.elementor-size-small{font-size:15px}.elementor-widget-heading .elementor-heading-title.elementor-size-medium{font-size:19px}.elementor-widget-heading .elementor-heading-title.elementor-size-large{font-size:29px}.elementor-widget-heading .elementor-heading-title.elementor-size-xl{font-size:39px}.elementor-widget-heading .elementor-heading-title.elementor-size-xxl{font-size:59px}<\/style><h1 class=\"elementor-heading-title elementor-size-default\">Soluzioni per la riduzione dell'aggregazione proteica Pfanstiehl <\/h1>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3f2991f8 elementor-widget elementor-widget-text-editor\" data-id=\"3f2991f8\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.23.0 - 05-08-2024 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#69727d;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#69727d;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t<p>L&#8217;aggregazione proteica \u00e8 il raggruppamento spontaneo o l&#8217;aggregazione di molecole proteiche, con conseguente formazione di strutture pi\u00f9 grandi chiamate aggregati.<\/p>\n<\/p>\n<p>Questo fenomeno pu\u00f2 verificarsi durante la produzione, la conservazione o la somministrazione di terapie biologiche a base di proteine, che sono farmaci derivati da fonti biologiche, come proteine o anticorpi.<\/p><\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7b3a9757 e-flex e-con-boxed e-con e-child\" data-id=\"7b3a9757\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-21f9eea6 elementor-widget elementor-widget-image\" data-id=\"21f9eea6\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.23.0 - 05-08-2024 *\/\n.elementor-widget-image{text-align:center}.elementor-widget-image a{display:inline-block}.elementor-widget-image a img[src$=\".svg\"]{width:48px}.elementor-widget-image img{vertical-align:middle;display:inline-block}<\/style>\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"800\" height=\"491\" src=\"https:\/\/pfanstiehl.com\/wp-content\/uploads\/2024\/06\/sol-2-1024x629.png\" class=\"attachment-large size-large wp-image-2212\" alt=\"Aggregated Proteins suspended in Formulation Buffer\" srcset=\"https:\/\/pfanstiehl.com\/wp-content\/uploads\/2024\/06\/sol-2-1024x629.png 1024w, https:\/\/pfanstiehl.com\/wp-content\/uploads\/2024\/06\/sol-2-300x184.png 300w, https:\/\/pfanstiehl.com\/wp-content\/uploads\/2024\/06\/sol-2-768x472.png 768w, https:\/\/pfanstiehl.com\/wp-content\/uploads\/2024\/06\/sol-2-600x368.png 600w, https:\/\/pfanstiehl.com\/wp-content\/uploads\/2024\/06\/sol-2.png 1140w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-cede383 e-flex e-con-boxed e-con e-parent\" data-id=\"cede383\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a3fbdc9 elementor-widget elementor-widget-text-editor\" data-id=\"a3fbdc9\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h2>Escipienti di alta qualit\u00e0, di grado GMP, possono fare tutta la differenza<\/h2>\n<p>L&#8217;effetto dell&#8217;aggregazione proteica sulla qualit\u00e0 delle terapie biologiche \u00e8 una preoccupazione significativa nell&#8217;industria farmaceutica. Alcuni impatti chiave includono: <\/p><\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-782f6181 solutions_content_box e-flex e-con-boxed e-con e-parent\" data-id=\"782f6181\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-1687f1be e-flex e-con-boxed e-con e-child\" data-id=\"1687f1be\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6f0bd77d elementor-widget elementor-widget-text-editor\" data-id=\"6f0bd77d\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h4>Solubilit\u00e0 limitata:<\/h4>\n<p>Le proteine aggregate possono avere una solubilit\u00e0 ridotta, che pu\u00f2 richiedere concentrazioni pi\u00f9 basse della proteina terapeutica. Questa limitazione pu\u00f2 influire sulla dose massima che pu\u00f2 essere somministrata attraverso determinate vie, come le iniezioni intramuscolari (IM) o sottocutanee (SC), che potrebbero richiedere la somministrazione endovenosa (IV). <\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3134d5b8 e-flex e-con-boxed e-con e-child\" data-id=\"3134d5b8\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4ed90b44 elementor-widget elementor-widget-text-editor\" data-id=\"4ed90b44\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h4>Variazioni della viscosit\u00e0 della soluzione:<\/h4>\n<p>A seconda della natura degli aggregati, possono verificarsi variazioni nella viscosit\u00e0 della soluzione. Gli aggregati compatti possono ridurre la viscosit\u00e0, mentre le strutture estese che possono aggrovigliarsi l&#8217;una con l&#8217;altra possono aumentare la viscosit\u00e0. Ci\u00f2 pu\u00f2 influire sulla facilit\u00e0 di somministrazione, in particolare nella somministrazione di IM o SC.  <\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-30bd9344 e-flex e-con-boxed e-con e-child\" data-id=\"30bd9344\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e3eb538 elementor-widget elementor-widget-text-editor\" data-id=\"e3eb538\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h4>Prodotti di degradazione:<\/h4>\n<p>Gli aggregati irreversibili sono considerati prodotti di degradazione. Se presenti nel flusso sanguigno, possono comportare rischi di risposte immunitarie nei pazienti. Ci\u00f2 pu\u00f2 portare i pazienti a sviluppare l&#8217;immunit\u00e0 alla proteina terapeutica o, in rari casi, provocare malattie autoimmuni.  <\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7dca49ab e-flex e-con-boxed e-con e-child\" data-id=\"7dca49ab\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-339a3894 elementor-widget elementor-widget-text-editor\" data-id=\"339a3894\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h4>Considerazioni di marketing:<\/h4>\n<p>Gli aggregati visibili sono spesso visti negativamente dal punto di vista del marketing. I pazienti e i medici in genere si aspettano che i prodotti iniettabili siano trasparenti e privi di particelle visibili. La presenza di aggregati pu\u00f2 sollevare preoccupazioni sulla sicurezza e l&#8217;efficacia del prodotto.  <\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3e87c2e6 e-flex e-con-boxed e-con e-parent\" data-id=\"3e87c2e6\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-33176ebe elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"33176ebe\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.23.0 - 05-08-2024 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var(--divider-color)}.elementor-widget-divider--separator-type-pattern{--divider-border-style:none}.elementor-widget-divider--separator-type-pattern.elementor-widget-divider--view-line .elementor-divider-separator,.elementor-widget-divider--separator-type-pattern:not(.elementor-widget-divider--view-line) .elementor-divider-separator:after,.elementor-widget-divider--separator-type-pattern:not(.elementor-widget-divider--view-line) .elementor-divider-separator:before,.elementor-widget-divider--separator-type-pattern:not([class*=elementor-widget-divider--view]) .elementor-divider-separator{width:100%;min-height:var(--divider-pattern-height);-webkit-mask-size:var(--divider-pattern-size) 100%;mask-size:var(--divider-pattern-size) 100%;-webkit-mask-repeat:var(--divider-pattern-repeat);mask-repeat:var(--divider-pattern-repeat);background-color:var(--divider-color);-webkit-mask-image:var(--divider-pattern-url);mask-image:var(--divider-pattern-url)}.elementor-widget-divider--no-spacing{--divider-pattern-size:auto}.elementor-widget-divider--bg-round{--divider-pattern-repeat:round}.rtl .elementor-widget-divider .elementor-divider__text{direction:rtl}.e-con-inner>.elementor-widget-divider,.e-con>.elementor-widget-divider{width:var(--container-widget-width,100%);--flex-grow:var(--container-widget-flex-grow)}<\/style>\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-5e0ec00b e-flex e-con-boxed e-con e-parent\" data-id=\"5e0ec00b\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-337a9bb3 elementor-widget elementor-widget-text-editor\" data-id=\"337a9bb3\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h3>Cosa pu\u00f2 fare Pfanstiehl per aiutare?<\/h3>\n<p>I Technical Sales Scientist di Pfanstiehl possono discutere con voi per comprendere le vostre sfide e fornire indicazioni basate sull&#8217;esperienza e sulle revisioni della letteratura per contribuire a mitigare l&#8217;aggregazione proteica nelle terapie biologiche. Controllare e ridurre al minimo l&#8217;aggregazione \u00e8 fondamentale per mantenere la sicurezza, l&#8217;efficacia e la qualit\u00e0 di questi farmaci. Aiutiamo a mettere insieme alcune idee per:  <\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-aefc7b4 solutions_links_margin elementor-widget elementor-widget-text-editor\" data-id=\"aefc7b4\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h5>Ottimizzazione della formulazione:<\/h5>\n<h4>Stabilizzanti ed eccipienti:<\/h4>\n<p>L&#8217;aggiunta di stabilizzanti, come zuccheri, polioli o tensioattivi, pu\u00f2 aiutare a prevenire l&#8217;aggregazione stabilizzando la struttura proteica e riducendo le interazioni intermolecolari.<\/p>\n<p><a href=\"https:\/\/pfanstiehl.com\/it\/categoria-prodotto\/sucrose-it\/\">Pfanstiehl HPLE-LM<sup>TM<\/sup> Saccarosio<\/a><br \/><a href=\"\/en?product_cat=trehalose\">Pfanstiehl HPLE-LM<sup>TM<\/sup> TREALOSIO<\/a><br \/><a href=\"https:\/\/pfanstiehl.com\/it\/categoria-prodotto\/maltose-it\/\">Pfanstiehl HPLE-LM<sup>TM<\/sup> Maltosio<\/a><br \/><a href=\"https:\/\/pfanstiehl.com\/it\/categoria-prodotto\/d-mannitolo\/\">Pfanstiehl HPLE-LM<sup>TM<\/sup> Mannitol<\/a><\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-637f0104 e-flex e-con-boxed e-con e-parent\" data-id=\"637f0104\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-70523d93 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"70523d93\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-573963b e-flex e-con-boxed e-con e-parent\" data-id=\"573963b\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-27b83d4 elementor-widget elementor-widget-text-editor\" data-id=\"27b83d4\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h4>Amminoacidi:<\/h4>\n<p>Gli amminoacidi svolgono un ruolo chiave nella riduzione <strong data-start=\"40\" data-end=\"63\">dell&#8217;aggregazione proteica<\/strong> nei biologici, un ruolo fondamentale per mantenere la <strong data-start=\"116\" data-end=\"151\">stabilit\u00e0, l&#8217;efficacia e la sicurezza<\/strong> delle proteine terapeutiche come gli anticorpi monoclonali o gli enzimi.  <\/p>\n<p><a href=\"https:\/\/pfanstiehl.com\/it\/categoria-prodotto\/arginine-it\/\">Pfanstiehl HPLE-LM L-Arginina<\/a><\/p>\n<p><a href=\"https:\/\/pfanstiehl.com\/it\/categoria-prodotto\/arginina-hcl-it\/\">Pfanstiehl HPLE-LM L-Arginina Hcl<\/a><\/p>\n<p><a href=\"https:\/\/pfanstiehl.com\/it\/categoria-prodotto\/glicina-eccipiente-multi-compendiale-gmp\/\">Pfanstiehl HPLE-LM Glicina<\/a><\/p>\n<p><a href=\"https:\/\/pfanstiehl.com\/it\/categoria-prodotto\/arginina-glutammato\/\">Pfanstiehl HPLE-LM Glutammato di arginina<\/a><\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4af7bf5 solutions_links_margin elementor-widget elementor-widget-text-editor\" data-id=\"4af7bf5\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h4>Sistemi tampone:<\/h4>\n<p>Una corretta selezione dei sistemi tampone pu\u00f2 aiutare a mantenere la stabilit\u00e0 e la solubilit\u00e0 della proteina. Mantenere il pH ottimale per una particolare proteina \u00e8 fondamentale. <\/p>\n<p><a href=\"https:\/\/pfanstiehl.com\/it\/categoria-prodotto\/tris-base-it\/\">Pfanstiehl HPLE-LM<sup>TM<\/sup> TRIS Base<\/a><br \/><a href=\"\/en?product_cat=tris-hcl\">Pfanstiehl HPLE-LM<sup>TM<\/sup> Tris HCL<\/a><br \/><a href=\"https:\/\/pfanstiehl.com\/it\/categoria-prodotto\/succinato-di-sodio-esaidrato\/\">Pfanstiehl HPLE-LM<sup>TM<\/sup> Succinato di sodio<\/a><\/p>\n<p><a href=\"https:\/\/pfanstiehl.com\/it\/categoria-prodotto\/acido-succinico\/\">Pfanstiehl HPLE-LM<sup>TM<\/sup> Acido Succinico<\/a><\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-4da3a94d e-flex e-con-boxed e-con e-parent\" data-id=\"4da3a94d\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-75791f76 elementor-widget elementor-widget-text-editor\" data-id=\"75791f76\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h2>Prova la differenza &#8211; Contatta Pfanstiehl oggi stesso!<\/h2>\n<p>Da oltre 100 anni, Pfanstiehl produce escipienti, stabilizzanti e componenti tampone iniettabili di grado cGMP garantiti ad alta purezza e bassa endotossina. I componenti Pfanstiehl sono utilizzati nella maggior parte dei farmaci pi\u00f9 venduti al mondo e continuiamo a crescere ogni anno.   <\/p>\n<\/p>\n<p>I nostri clienti sanno che i componenti cGMP ad alta purezza ad alta purezza di Pfanstiehl aiuteranno a garantire una migliore consistenza da lotto a lotto e a ridurre il rischio di fallimento della produzione per il tuo terapeutico.<\/p>\n<\/p>\n<p>Se possiedi un biologico proteico o vaccino che richiede <strong>elevata purezza ed escipienti di endotossine basse,<\/strong> ti preghiamo di contattarci.<\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-62bccdf6 elementor-widget elementor-widget-button\" data-id=\"62bccdf6\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" 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