{"id":4957,"date":"2024-05-21T11:35:56","date_gmt":"2024-05-21T11:35:56","guid":{"rendered":"https:\/\/pfanstiehl.com\/solutions\/formulations-a-haute-concentration\/"},"modified":"2024-07-08T06:04:53","modified_gmt":"2024-07-08T06:04:53","slug":"formulations-a-haute-concentration","status":"publish","type":"solutions","link":"https:\/\/pfanstiehl.com\/fr\/solutions\/formulations-a-haute-concentration\/","title":{"rendered":"Formulations \u00e0 haute concentration"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"4957\" class=\"elementor elementor-4957 elementor-456\" data-elementor-post-type=\"solutions\">\n\t\t\t\t<div class=\"elementor-element elementor-element-24f53088 e-flex e-con-boxed e-con e-parent\" data-id=\"24f53088\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-d124f80 e-flex e-con-boxed e-con e-child\" data-id=\"d124f80\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-216f275b elementor-widget elementor-widget-heading\" data-id=\"216f275b\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.23.0 - 05-08-2024 *\/\n.elementor-heading-title{padding:0;margin:0;line-height:1}.elementor-widget-heading .elementor-heading-title[class*=elementor-size-]>a{color:inherit;font-size:inherit;line-height:inherit}.elementor-widget-heading .elementor-heading-title.elementor-size-small{font-size:15px}.elementor-widget-heading .elementor-heading-title.elementor-size-medium{font-size:19px}.elementor-widget-heading .elementor-heading-title.elementor-size-large{font-size:29px}.elementor-widget-heading .elementor-heading-title.elementor-size-xl{font-size:39px}.elementor-widget-heading .elementor-heading-title.elementor-size-xxl{font-size:59px}<\/style><h1 class=\"elementor-heading-title elementor-size-default\">Solutions Pfanstiehl pour la formulation d\u2019anticorps \u00e0 haute concentration<\/h1>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1bd54bf2 elementor-widget elementor-widget-text-editor\" data-id=\"1bd54bf2\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.23.0 - 05-08-2024 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#69727d;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#69727d;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t<p>Le d\u00e9veloppement de formulations d\u2019anticorps \u00e0 haute concentration (HCAF) sup\u00e9rieures \u00e0 100 mg\/ml est essentiel pour la cr\u00e9ation de th\u00e9rapies par anticorps monoclonaux (mAb) pouvant \u00eatre administr\u00e9es par voie sous-cutan\u00e9e. Cependant, la variabilit\u00e9 in\u00e9vitable entre les mol\u00e9cules cr\u00e9e des d\u00e9fis techniques complexes qui n\u00e9cessitent un large \u00e9ventail d\u2019outils et d\u2019expertise pour \u00eatre r\u00e9solus.  <\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-263b929c e-flex e-con-boxed e-con e-child\" data-id=\"263b929c\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-45e34127 elementor-widget elementor-widget-image\" data-id=\"45e34127\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.23.0 - 05-08-2024 *\/\n.elementor-widget-image{text-align:center}.elementor-widget-image a{display:inline-block}.elementor-widget-image a img[src$=\".svg\"]{width:48px}.elementor-widget-image img{vertical-align:middle;display:inline-block}<\/style>\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"800\" height=\"491\" src=\"https:\/\/pfanstiehl.com\/wp-content\/uploads\/2024\/06\/sol-4-1024x629.png\" class=\"attachment-large size-large wp-image-2214\" alt=\"\" srcset=\"https:\/\/pfanstiehl.com\/wp-content\/uploads\/2024\/06\/sol-4-1024x629.png 1024w, https:\/\/pfanstiehl.com\/wp-content\/uploads\/2024\/06\/sol-4-300x184.png 300w, https:\/\/pfanstiehl.com\/wp-content\/uploads\/2024\/06\/sol-4-768x472.png 768w, https:\/\/pfanstiehl.com\/wp-content\/uploads\/2024\/06\/sol-4-600x368.png 600w, https:\/\/pfanstiehl.com\/wp-content\/uploads\/2024\/06\/sol-4.png 1140w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-464af55 solutions_content_box e-flex e-con-boxed e-con e-parent\" data-id=\"464af55\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-81986c7 e-flex e-con-boxed e-con e-child\" data-id=\"81986c7\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-37b8a322 elementor-widget elementor-widget-text-editor\" data-id=\"37b8a322\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h4>D\u00e9fis de la viscosit\u00e9 et de la solubilit\u00e9 :<\/h4>\n<p>L\u2019un des principaux obstacles au d\u00e9veloppement du HCAF est l\u2019augmentation in\u00e9vitable de la viscosit\u00e9 de la solution \u00e0 mesure que la concentration d\u2019anticorps monoclonaux augmente. Cette augmentation de la viscosit\u00e9 pose des d\u00e9fis lors de la filtration, du remplissage et d\u2019autres processus de fabrication. De plus, les solutions d\u2019anticorps monoclonaux hautement concentr\u00e9es peuvent rencontrer des limitations de solubilit\u00e9, entra\u00eenant une g\u00e9lification ou une s\u00e9paration de phase, en particulier dans des conditions r\u00e9frig\u00e9r\u00e9es. De tels \u00e9v\u00e9nements compromettent non seulement la stabilit\u00e9 de la formulation, mais menacent \u00e9galement l\u2019efficacit\u00e9 th\u00e9rapeutique.<\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-69a1ba89 e-flex e-con-boxed e-con e-child\" data-id=\"69a1ba89\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4f1007fa elementor-widget elementor-widget-text-editor\" data-id=\"4f1007fa\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h4>D\u00e9fis du proc\u00e9d\u00e9 de fabrication:<\/h4>\n<p>Le processus de formulation lui-m\u00eame cr\u00e9e des d\u00e9fis complexes, en particulier dans les op\u00e9rations unitaires telles que l\u2019ultrafiltration-diafiltration, la filtration st\u00e9rile et les \u00e9tapes de remplissage-finition. Ces d\u00e9fis peuvent entraver l\u2019efficacit\u00e9 de la fabrication et faire grimper les co\u00fbts, n\u00e9cessitant des solutions innovantes pour rationaliser les processus sans compromettre la qualit\u00e9 des produits.<\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-4abc820e e-flex e-con-boxed e-con e-child\" data-id=\"4abc820e\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c7ff810 elementor-widget elementor-widget-text-editor\" data-id=\"c7ff810\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h4>Probl\u00e8mes de seringue et d\u2019injectabilit\u00e9 :<\/h4>\n<p>La viscosit\u00e9 \u00e9lev\u00e9e et l\u2019agr\u00e9gation d\u2019anticorps monoclonaux entravent non seulement les processus de fabrication, mais compromettent \u00e9galement la seringue et l\u2019injectabilit\u00e9 pendant l\u2019administration du patient. Ces probl\u00e8mes r\u00e9duisent l\u2019observance du patient et l\u2019efficacit\u00e9 du traitement, soulignant l\u2019importance des formulations optimis\u00e9es pour une administration facile.<\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-230443da e-flex e-con-boxed e-con e-child\" data-id=\"230443da\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-15829f69 elementor-widget elementor-widget-text-editor\" data-id=\"15829f69\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h4>Agr\u00e9gation des prot\u00e9ines et stabilit\u00e9 le stockage :<\/h4>\n<p>L\u2019agr\u00e9gation des prot\u00e9ines pr\u00e9sente un risque important lors de la fabrication et de l\u2019administration, ce qui peut entra\u00eener une diminution de la puissance th\u00e9rapeutique. De plus, la formation d\u2019agr\u00e9gats augmente le risque de d\u00e9clencher des r\u00e9ponses immunitaires anti-m\u00e9dicamenteuses, soulignant la n\u00e9cessit\u00e9 de maintenir la stabilit\u00e9 de stockage \u00e0 long terme tout en pr\u00e9servant l\u2019int\u00e9grit\u00e9 de la formulation.<\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6a9163fc e-flex e-con-boxed e-con e-child\" data-id=\"6a9163fc\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-693d7bc elementor-widget elementor-widget-text-editor\" data-id=\"693d7bc\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h4>Excipients et complexit\u00e9 de la formulation :<\/h4>\n<p>Les excipients jouent un r\u00f4le central dans l\u2019att\u00e9nuation de la viscosit\u00e9, l\u2019am\u00e9lioration de la solubilit\u00e9 et la stabilit\u00e9 des formulations HCAF. Cependant, s\u00e9lectionner les bons excipients tout en maintenant la stabilit\u00e9 de la formulation reste un art m\u00e9lang\u00e9 \u00e0 la science.  <\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2020c36e e-flex e-con-boxed e-con e-parent\" data-id=\"2020c36e\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1063cfe5 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"1063cfe5\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.23.0 - 05-08-2024 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.elementor-divider__element{margin-right:0}.elementor-widget-divider--element-align-start .elementor-divider .elementor-divider-separator>.elementor-divider__svg:first-of-type{flex-grow:0;flex-shrink:100}.elementor-widget-divider--element-align-start .elementor-divider-separator:before{content:none}.elementor-widget-divider--element-align-start .elementor-divider__element{margin-inline-start:0}.elementor-widget-divider--element-align-end .elementor-divider .elementor-divider-separator>.elementor-divider__svg:last-of-type{flex-grow:0;flex-shrink:100}.elementor-widget-divider--element-align-end .elementor-divider-separator:after{content:none}.elementor-widget-divider--element-align-end .elementor-divider__element{margin-inline-end:0}.elementor-widget-divider:not(.elementor-widget-divider--view-line_text):not(.elementor-widget-divider--view-line_icon) .elementor-divider-separator{border-block-start:var(--divider-border-width) var(--divider-border-style) var(--divider-color)}.elementor-widget-divider--separator-type-pattern{--divider-border-style:none}.elementor-widget-divider--separator-type-pattern.elementor-widget-divider--view-line .elementor-divider-separator,.elementor-widget-divider--separator-type-pattern:not(.elementor-widget-divider--view-line) .elementor-divider-separator:after,.elementor-widget-divider--separator-type-pattern:not(.elementor-widget-divider--view-line) .elementor-divider-separator:before,.elementor-widget-divider--separator-type-pattern:not([class*=elementor-widget-divider--view]) .elementor-divider-separator{width:100%;min-height:var(--divider-pattern-height);-webkit-mask-size:var(--divider-pattern-size) 100%;mask-size:var(--divider-pattern-size) 100%;-webkit-mask-repeat:var(--divider-pattern-repeat);mask-repeat:var(--divider-pattern-repeat);background-color:var(--divider-color);-webkit-mask-image:var(--divider-pattern-url);mask-image:var(--divider-pattern-url)}.elementor-widget-divider--no-spacing{--divider-pattern-size:auto}.elementor-widget-divider--bg-round{--divider-pattern-repeat:round}.rtl .elementor-widget-divider .elementor-divider__text{direction:rtl}.e-con-inner>.elementor-widget-divider,.e-con>.elementor-widget-divider{width:var(--container-widget-width,100%);--flex-grow:var(--container-widget-flex-grow)}<\/style>\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-43a2f69 e-flex e-con-boxed e-con e-parent\" data-id=\"43a2f69\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6f3af571 elementor-widget elementor-widget-text-editor\" data-id=\"6f3af571\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h3>Que peut faire Pfanstiehl pour aider ?<\/h3>\n<p>Les scientifiques technico-commerciaux de Pfanstiehl peuvent discuter avec vous pour comprendre vos d\u00e9fis et vous fournir des conseils bas\u00e9s sur l\u2019exp\u00e9rience et les revues de litt\u00e9rature pour r\u00e9duire la viscosit\u00e9 et stabiliser la structure et l\u2019activit\u00e9 biologique de votre prot\u00e9ine th\u00e9rapeutique.<\/p>\n<p>Laissez-nous vous aider \u00e0 rassembler quelques id\u00e9es pour :<\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-53349a58 solutions_content_box e-flex e-con-boxed e-con e-child\" data-id=\"53349a58\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-537e2e9a e-flex e-con-boxed e-con e-child\" data-id=\"537e2e9a\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-75102716 elementor-widget elementor-widget-text-editor\" data-id=\"75102716\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h4>Agents stabilisants :<\/h4><p>L\u2019incorporation d\u2019agents stabilisants comme les sucres ou les polyols peut prot\u00e9ger les prot\u00e9ines de la d\u00e9naturation et de l\u2019agr\u00e9gation pendant le stockage et la manipulation.<\/p><p><a href=\"https:\/\/pfanstiehl.com\/fr\/categorie-produit\/saccharose-fr\/\">Pfanstiehl HPLE-LM<sup>TM<\/sup> Saccharose<\/a><br \/><a href=\"https:\/\/pfanstiehl.com\/fr\/categorie-produit\/trehalose-fr\/\">Pfanstiehl HPLE-LM<sup>TM<\/sup> Tr\u00e9halose<\/a><br \/><a href=\"https:\/\/pfanstiehl.com\/fr\/categorie-produit\/maltose-fr\/\">Pfanstiehl HPLE-LM<sup>TM<\/sup> Maltose<\/a><br \/><a href=\"https:\/\/pfanstiehl.com\/fr\/categorie-produit\/d-mannitol-fr\/\">Pfanstiehl HPLE-LM<sup>TM<\/sup> Mannitol<\/a><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6cfb8826 e-flex e-con-boxed e-con e-child\" data-id=\"6cfb8826\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-50e4843d elementor-widget elementor-widget-text-editor\" data-id=\"50e4843d\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h4>Utilisation d\u2019excipients r\u00e9duisant la viscosit\u00e9<\/h4><p>L\u2019incorporation d\u2019excipients r\u00e9duisant la viscosit\u00e9 comme l\u2019arginine, le chlorure de sodium ou des acides amin\u00e9s sp\u00e9cifiques peut att\u00e9nuer les augmentations de viscosit\u00e9 tout en maintenant la stabilit\u00e9.<\/p><p><a href=\"https:\/\/pfanstiehl.com\/fr\/categorie-produit\/arginine-fr\/\">Pfanstiehl HPLE-LM<sup>TM<\/sup> L-Arginine<\/a><br \/><a href=\"https:\/\/pfanstiehl.com\/fr\/categorie-produit\/arginine-hcl-fr\/\">Pfanstiehl HPLE-LM<sup>TM<\/sup> L-Arginine HCL<\/a><br \/><a href=\"https:\/\/pfanstiehl.com\/fr\/categorie-produit\/histidine-fr\/\">Pfanstiehl HPLE-LM<sup>TM<\/sup> L-histidine<\/a><br \/><a href=\"https:\/\/pfanstiehl.com\/fr\/categorie-produit\/histidine-hcl-fr\/\">Pfanstiehl HPLE-LM<sup>TM<\/sup> L-Histidine HCL<\/a><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-49c2453d e-flex e-con-boxed e-con e-child\" data-id=\"49c2453d\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-316d5370 elementor-widget elementor-widget-text-editor\" data-id=\"316d5370\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h4>Optimisation des syst\u00e8mes tampons :<\/h4><p>L\u2019ajustement du pH et de la composition du syst\u00e8me tampon peut am\u00e9liorer la solubilit\u00e9 et la stabilit\u00e9, ce qui est crucial pour les formulations \u00e0 forte concentration.<\/p><p><a href=\"https:\/\/pfanstiehl.com\/fr\/categorie-produit\/tris-base-fr\/\">Pfanstiehl HPLE-LM<sup>TM<\/sup> TRIS Base<\/a><br \/><a href=\"https:\/\/pfanstiehl.com\/fr\/categorie-produit\/tris-hcl-fr\/\">Pfanstiehl HPLE-LM<sup>TM<\/sup> Tris HCL<\/a><br \/><a href=\"https:\/\/pfanstiehl.com\/fr\/categorie-produit\/succinate-de-sodium-hexahydrate\/\">Pfanstiehl HPLE-LM<sup>TM<\/sup> Succinate de sodium<\/a><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-31f233cb e-flex e-con-boxed e-con e-parent\" data-id=\"31f233cb\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2510ad33 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"2510ad33\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-128d7df3 e-flex e-con-boxed e-con e-parent\" data-id=\"128d7df3\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2a64ed02 elementor-widget elementor-widget-text-editor\" data-id=\"2a64ed02\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Depuis plus de 100 ans, Pfanstiehl fabrique des excipients, des stabilisants et des composants tampons de qualit\u00e9 injectable cGMP qui garantissent une grande puret\u00e9 et une faible teneur en endotoxines. Nos composants sont utilis\u00e9s dans la majorit\u00e9 des produits biopharmaceutiques les plus vendus au monde et nous continuons \u00e0 cro\u00eetre chaque ann\u00e9e.  <\/p>\n<\/p>\n<p>Nos clients savent que la combinaison du support technique prim\u00e9 de Pfanstiehl et des composants cGMP de haute puret\u00e9 \u00e0 faible teneur en endotoxines contribuera \u00e0 assurer une meilleure coh\u00e9rence d\u2019un lot \u00e0 l\u2019autre et \u00e0 r\u00e9duire le risque d\u2019\u00e9chec de la fabrication de votre produit th\u00e9rapeutique.<\/p>\n<\/p>\n<p>Si vous avez un produit biologique ou un vaccin prot\u00e9ique qui n\u00e9cessite une formulation d\u2019anticorps \u00e0 haute concentration (HCAF), veuillez nous contacter et nous serons heureux de discuter de la mani\u00e8re dont nous pouvons travailler ensemble pour rendre votre produit de la plus haute qualit\u00e9 possible.<\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4aa77fc elementor-widget elementor-widget-button\" data-id=\"4aa77fc\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/pfanstiehl.com\/fr\/contactez-nous\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Contactez-nous<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7ecdf034 e-con-full right_fixed_btn e-flex e-con e-parent\" data-id=\"7ecdf034\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6e2be36e fixed_desktop_btn elementor-widget elementor-widget-button\" data-id=\"6e2be36e\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/pfanstiehl.com\/fr\/contactez-nous\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Contactez-nous<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cd96f04 fixed_mobile_btn elementor-widget elementor-widget-button\" data-id=\"cd96f04\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/pfanstiehl.com\/fr\/contactez-nous\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-far-envelope\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M464 64H48C21.49 64 0 85.49 0 112v288c0 26.51 21.49 48 48 48h416c26.51 0 48-21.49 48-48V112c0-26.51-21.49-48-48-48zm0 48v40.805c-22.422 18.259-58.168 46.651-134.587 106.49-16.841 13.247-50.201 45.072-73.413 44.701-23.208.375-56.579-31.459-73.413-44.701C106.18 199.465 70.425 171.067 48 152.805V112h416zM48 400V214.398c22.914 18.251 55.409 43.862 104.938 82.646 21.857 17.205 60.134 55.186 103.062 54.955 42.717.231 80.509-37.199 103.053-54.947 49.528-38.783 82.032-64.401 104.947-82.653V400H48z\"><\/path><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"featured_media":0,"menu_order":0,"template":"elementor_header_footer","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_uf_show_specific_survey":0,"_uf_disable_surveys":false},"class_list":["post-4957","solutions","type-solutions","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - 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Cependant, la variabilit\u00e9 in\u00e9vitable entre les mol\u00e9cules cr\u00e9e des d\u00e9fis techniques complexes qui n\u00e9cessitent un large [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/pfanstiehl.com\/fr\/solutions\/formulations-a-haute-concentration\/\" \/>\n<meta property=\"og:site_name\" content=\"Pfanstiehl\" \/>\n<meta property=\"article:modified_time\" content=\"2024-07-08T06:04:53+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/pfanstiehl.com\/wp-content\/uploads\/2024\/06\/sol-4-1024x629.png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data1\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/pfanstiehl.com\\\/fr\\\/solutions\\\/formulations-a-haute-concentration\\\/\",\"url\":\"https:\\\/\\\/pfanstiehl.com\\\/fr\\\/solutions\\\/formulations-a-haute-concentration\\\/\",\"name\":\"Formulations \u00e0 haute concentration - Pfanstiehl\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/pfanstiehl.com\\\/fr\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/pfanstiehl.com\\\/fr\\\/solutions\\\/formulations-a-haute-concentration\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/pfanstiehl.com\\\/fr\\\/solutions\\\/formulations-a-haute-concentration\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/pfanstiehl.com\\\/wp-content\\\/uploads\\\/2024\\\/06\\\/sol-4-1024x629.png\",\"datePublished\":\"2024-05-21T11:35:56+00:00\",\"dateModified\":\"2024-07-08T06:04:53+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/pfanstiehl.com\\\/fr\\\/solutions\\\/formulations-a-haute-concentration\\\/#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/pfanstiehl.com\\\/fr\\\/solutions\\\/formulations-a-haute-concentration\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\\\/\\\/pfanstiehl.com\\\/fr\\\/solutions\\\/formulations-a-haute-concentration\\\/#primaryimage\",\"url\":\"https:\\\/\\\/pfanstiehl.com\\\/wp-content\\\/uploads\\\/2024\\\/06\\\/sol-4-1024x629.png\",\"contentUrl\":\"https:\\\/\\\/pfanstiehl.com\\\/wp-content\\\/uploads\\\/2024\\\/06\\\/sol-4-1024x629.png\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/pfanstiehl.com\\\/fr\\\/solutions\\\/formulations-a-haute-concentration\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/pfanstiehl.com\\\/fr\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Formulations \u00e0 haute concentration\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/pfanstiehl.com\\\/fr\\\/#website\",\"url\":\"https:\\\/\\\/pfanstiehl.com\\\/fr\\\/\",\"name\":\"Pfanstiehl\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\\\/\\\/pfanstiehl.com\\\/fr\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/pfanstiehl.com\\\/fr\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"fr-FR\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/pfanstiehl.com\\\/fr\\\/#organization\",\"name\":\"Pfanstiehl\",\"url\":\"https:\\\/\\\/pfanstiehl.com\\\/fr\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\\\/\\\/pfanstiehl.com\\\/fr\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/pfanstiehl.com\\\/wp-content\\\/uploads\\\/2024\\\/06\\\/logo.png\",\"contentUrl\":\"https:\\\/\\\/pfanstiehl.com\\\/wp-content\\\/uploads\\\/2024\\\/06\\\/logo.png\",\"width\":600,\"height\":85,\"caption\":\"Pfanstiehl\"},\"image\":{\"@id\":\"https:\\\/\\\/pfanstiehl.com\\\/fr\\\/#\\\/schema\\\/logo\\\/image\\\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Formulations \u00e0 haute concentration - Pfanstiehl","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/pfanstiehl.com\/fr\/solutions\/formulations-a-haute-concentration\/","og_locale":"fr_FR","og_type":"article","og_title":"Formulations \u00e0 haute concentration - Pfanstiehl","og_description":"Solutions Pfanstiehl pour la formulation d\u2019anticorps \u00e0 haute concentration Le d\u00e9veloppement de formulations d\u2019anticorps \u00e0 haute concentration (HCAF) sup\u00e9rieures \u00e0 100 mg\/ml est essentiel pour la cr\u00e9ation de th\u00e9rapies par anticorps monoclonaux (mAb) pouvant \u00eatre administr\u00e9es par voie sous-cutan\u00e9e. 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