{"id":4937,"date":"2024-05-21T11:01:18","date_gmt":"2024-05-21T11:01:18","guid":{"rendered":"https:\/\/pfanstiehl.com\/solutions\/reduction-de-lagregation-des-proteines\/"},"modified":"2024-07-05T07:50:11","modified_gmt":"2024-07-05T07:50:11","slug":"reduction-de-lagregation-des-proteines","status":"publish","type":"solutions","link":"https:\/\/pfanstiehl.com\/fr\/solutions\/reduction-de-lagregation-des-proteines\/","title":{"rendered":"R\u00e9duction de l\u2019agr\u00e9gation des prot\u00e9ines"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"4937\" class=\"elementor elementor-4937 elementor-372\" data-elementor-post-type=\"solutions\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4553736b e-flex e-con-boxed e-con e-parent\" data-id=\"4553736b\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-37688f53 e-flex e-con-boxed e-con e-child\" data-id=\"37688f53\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1769ebe9 elementor-widget elementor-widget-heading\" data-id=\"1769ebe9\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.23.0 - 05-08-2024 *\/\n.elementor-heading-title{padding:0;margin:0;line-height:1}.elementor-widget-heading .elementor-heading-title[class*=elementor-size-]>a{color:inherit;font-size:inherit;line-height:inherit}.elementor-widget-heading .elementor-heading-title.elementor-size-small{font-size:15px}.elementor-widget-heading .elementor-heading-title.elementor-size-medium{font-size:19px}.elementor-widget-heading .elementor-heading-title.elementor-size-large{font-size:29px}.elementor-widget-heading .elementor-heading-title.elementor-size-xl{font-size:39px}.elementor-widget-heading .elementor-heading-title.elementor-size-xxl{font-size:59px}<\/style><h1 class=\"elementor-heading-title elementor-size-default\">Solutions pour la r\u00e9duction de l\u2019agr\u00e9gation des prot\u00e9ines Pfanstiehl<\/h1>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3f2991f8 elementor-widget elementor-widget-text-editor\" data-id=\"3f2991f8\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.23.0 - 05-08-2024 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#69727d;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#69727d;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t<p>L\u2019agr\u00e9gation de prot\u00e9ines est le regroupement spontan\u00e9 ou l\u2019agglutination de mol\u00e9cules de prot\u00e9ines, entra\u00eenant la formation de structures plus grandes appel\u00e9es agr\u00e9gats. Ce ph\u00e9nom\u00e8ne peut se produire lors de la fabrication, du stockage ou de l\u2019administration de produits biologiques th\u00e9rapeutiques \u00e0 base de prot\u00e9ines, qui sont des m\u00e9dicaments d\u00e9riv\u00e9s de sources biologiques, telles que des prot\u00e9ines ou des anticorps.<\/p>\n<\/p>\n<p>L\u2019effet de l\u2019agr\u00e9gation des prot\u00e9ines sur la qualit\u00e9 des th\u00e9rapies biologiques est une pr\u00e9occupation importante dans l\u2019industrie pharmaceutique. Voici quelques-uns des principaux impacts :<\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7b3a9757 e-flex e-con-boxed e-con e-child\" data-id=\"7b3a9757\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-21f9eea6 elementor-widget elementor-widget-image\" data-id=\"21f9eea6\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.23.0 - 05-08-2024 *\/\n.elementor-widget-image{text-align:center}.elementor-widget-image a{display:inline-block}.elementor-widget-image a img[src$=\".svg\"]{width:48px}.elementor-widget-image img{vertical-align:middle;display:inline-block}<\/style>\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"800\" height=\"491\" src=\"https:\/\/pfanstiehl.com\/wp-content\/uploads\/2024\/06\/sol-2-1024x629.png\" class=\"attachment-large size-large wp-image-2212\" alt=\"Aggregated Proteins suspended in Formulation Buffer\" srcset=\"https:\/\/pfanstiehl.com\/wp-content\/uploads\/2024\/06\/sol-2-1024x629.png 1024w, https:\/\/pfanstiehl.com\/wp-content\/uploads\/2024\/06\/sol-2-300x184.png 300w, https:\/\/pfanstiehl.com\/wp-content\/uploads\/2024\/06\/sol-2-768x472.png 768w, https:\/\/pfanstiehl.com\/wp-content\/uploads\/2024\/06\/sol-2-600x368.png 600w, https:\/\/pfanstiehl.com\/wp-content\/uploads\/2024\/06\/sol-2.png 1140w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-782f6181 solutions_content_box e-flex e-con-boxed e-con e-parent\" data-id=\"782f6181\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-1687f1be e-flex e-con-boxed e-con e-child\" data-id=\"1687f1be\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6f0bd77d elementor-widget elementor-widget-text-editor\" data-id=\"6f0bd77d\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h4>Solubilit\u00e9 limit\u00e9e :<\/h4>\n<p>Les prot\u00e9ines agr\u00e9g\u00e9es peuvent avoir une solubilit\u00e9 r\u00e9duite, ce qui peut n\u00e9cessiter des concentrations plus faibles de la prot\u00e9ine th\u00e9rapeutique. Cette limitation peut avoir une incidence sur la dose maximale pouvant \u00eatre administr\u00e9e par certaines voies, telles que les injections intramusculaires (IM) ou sous-cutan\u00e9es (SC), n\u00e9cessitant potentiellement une administration intraveineuse (IV).<\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3134d5b8 e-flex e-con-boxed e-con e-child\" data-id=\"3134d5b8\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4ed90b44 elementor-widget elementor-widget-text-editor\" data-id=\"4ed90b44\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h4>Changements dans la viscosit\u00e9 de la solution :<\/h4>\n<p>Selon la nature des agr\u00e9gats, des changements de viscosit\u00e9 de la solution peuvent se produire. Les agr\u00e9gats compacts peuvent diminuer la viscosit\u00e9, tandis que les structures \u00e9tendues qui peuvent s\u2019emm\u00ealer les unes dans les autres peuvent augmenter la viscosit\u00e9. Cela peut nuire \u00e0 la facilit\u00e9 d\u2019administration, en particulier dans le cadre de la prestation de la GI ou de la SC.<\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-30bd9344 e-flex e-con-boxed e-con e-child\" data-id=\"30bd9344\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e3eb538 elementor-widget elementor-widget-text-editor\" data-id=\"e3eb538\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h4>Produits de d\u00e9gradation :<\/h4>\n<p>Les agr\u00e9gats irr\u00e9versibles sont consid\u00e9r\u00e9s comme des produits de d\u00e9gradation. S\u2019ils sont pr\u00e9sents dans la circulation sanguine, ils peuvent pr\u00e9senter des risques de r\u00e9ponses immunitaires chez les patients. Cela peut conduire les patients \u00e0 d\u00e9velopper une immunit\u00e9 \u00e0 la prot\u00e9ine th\u00e9rapeutique ou, dans de rares cas, entra\u00eener des maladies auto-immunes.<\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7dca49ab e-flex e-con-boxed e-con e-child\" data-id=\"7dca49ab\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-339a3894 elementor-widget elementor-widget-text-editor\" data-id=\"339a3894\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h4>Consid\u00e9rations marketing :<\/h4>\n<p>Les agr\u00e9gats visibles sont souvent per\u00e7us n\u00e9gativement d\u2019un point de vue marketing. Les patients et les cliniciens s\u2019attendent g\u00e9n\u00e9ralement \u00e0 ce que les produits injectables soient transparents et exempts de particules visibles. La pr\u00e9sence d\u2019agr\u00e9gats peut soulever des inqui\u00e9tudes quant \u00e0 l\u2019innocuit\u00e9 et \u00e0 l\u2019efficacit\u00e9 du produit.<\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3e87c2e6 e-flex e-con-boxed e-con e-parent\" data-id=\"3e87c2e6\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-33176ebe elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"33176ebe\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.23.0 - 05-08-2024 *\/\n.elementor-widget-divider{--divider-border-style:none;--divider-border-width:1px;--divider-color:#0c0d0e;--divider-icon-size:20px;--divider-element-spacing:10px;--divider-pattern-height:24px;--divider-pattern-size:20px;--divider-pattern-url:none;--divider-pattern-repeat:repeat-x}.elementor-widget-divider .elementor-divider{display:flex}.elementor-widget-divider .elementor-divider__text{font-size:15px;line-height:1;max-width:95%}.elementor-widget-divider .elementor-divider__element{margin:0 var(--divider-element-spacing);flex-shrink:0}.elementor-widget-divider .elementor-icon{font-size:var(--divider-icon-size)}.elementor-widget-divider .elementor-divider-separator{display:flex;margin:0;direction:ltr}.elementor-widget-divider--view-line_icon .elementor-divider-separator,.elementor-widget-divider--view-line_text .elementor-divider-separator{align-items:center}.elementor-widget-divider--view-line_icon .elementor-divider-separator:after,.elementor-widget-divider--view-line_icon .elementor-divider-separator:before,.elementor-widget-divider--view-line_text .elementor-divider-separator:after,.elementor-widget-divider--view-line_text .elementor-divider-separator:before{display:block;content:\"\";border-block-end:0;flex-grow:1;border-block-start:var(--divider-border-width) var(--divider-border-style) var(--divider-color)}.elementor-widget-divider--element-align-left .elementor-divider .elementor-divider-separator>.elementor-divider__svg:first-of-type{flex-grow:0;flex-shrink:100}.elementor-widget-divider--element-align-left .elementor-divider-separator:before{content:none}.elementor-widget-divider--element-align-left .elementor-divider__element{margin-left:0}.elementor-widget-divider--element-align-right .elementor-divider .elementor-divider-separator>.elementor-divider__svg:last-of-type{flex-grow:0;flex-shrink:100}.elementor-widget-divider--element-align-right .elementor-divider-separator:after{content:none}.elementor-widget-divider--element-align-right .elementor-divider__element{margin-right:0}.elementor-widget-divider--element-align-start .elementor-divider .elementor-divider-separator>.elementor-divider__svg:first-of-type{flex-grow:0;flex-shrink:100}.elementor-widget-divider--element-align-start .elementor-divider-separator:before{content:none}.elementor-widget-divider--element-align-start .elementor-divider__element{margin-inline-start:0}.elementor-widget-divider--element-align-end .elementor-divider .elementor-divider-separator>.elementor-divider__svg:last-of-type{flex-grow:0;flex-shrink:100}.elementor-widget-divider--element-align-end .elementor-divider-separator:after{content:none}.elementor-widget-divider--element-align-end .elementor-divider__element{margin-inline-end:0}.elementor-widget-divider:not(.elementor-widget-divider--view-line_text):not(.elementor-widget-divider--view-line_icon) .elementor-divider-separator{border-block-start:var(--divider-border-width) var(--divider-border-style) var(--divider-color)}.elementor-widget-divider--separator-type-pattern{--divider-border-style:none}.elementor-widget-divider--separator-type-pattern.elementor-widget-divider--view-line .elementor-divider-separator,.elementor-widget-divider--separator-type-pattern:not(.elementor-widget-divider--view-line) .elementor-divider-separator:after,.elementor-widget-divider--separator-type-pattern:not(.elementor-widget-divider--view-line) .elementor-divider-separator:before,.elementor-widget-divider--separator-type-pattern:not([class*=elementor-widget-divider--view]) .elementor-divider-separator{width:100%;min-height:var(--divider-pattern-height);-webkit-mask-size:var(--divider-pattern-size) 100%;mask-size:var(--divider-pattern-size) 100%;-webkit-mask-repeat:var(--divider-pattern-repeat);mask-repeat:var(--divider-pattern-repeat);background-color:var(--divider-color);-webkit-mask-image:var(--divider-pattern-url);mask-image:var(--divider-pattern-url)}.elementor-widget-divider--no-spacing{--divider-pattern-size:auto}.elementor-widget-divider--bg-round{--divider-pattern-repeat:round}.rtl .elementor-widget-divider .elementor-divider__text{direction:rtl}.e-con-inner>.elementor-widget-divider,.e-con>.elementor-widget-divider{width:var(--container-widget-width,100%);--flex-grow:var(--container-widget-flex-grow)}<\/style>\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-5e0ec00b e-flex e-con-boxed e-con e-parent\" data-id=\"5e0ec00b\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-337a9bb3 elementor-widget elementor-widget-text-editor\" data-id=\"337a9bb3\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h3>Que peut faire Pfanstiehl pour aider ?<\/h3>\n<p>Les scientifiques technico-commerciaux de Pfanstiehl peuvent discuter avec vous pour comprendre vos d\u00e9fis et vous fournir des conseils bas\u00e9s sur l\u2019exp\u00e9rience et les revues de litt\u00e9rature pour aider \u00e0 att\u00e9nuer l\u2019agr\u00e9gation des prot\u00e9ines dans les th\u00e9rapies biologiques. Le contr\u00f4le et la minimisation de l\u2019agr\u00e9gation sont essentiels pour maintenir l\u2019innocuit\u00e9, l\u2019efficacit\u00e9 et la qualit\u00e9 de ces m\u00e9dicaments. Laissez-nous vous aider \u00e0 rassembler quelques id\u00e9es pour :<\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-aefc7b4 solutions_links_margin elementor-widget elementor-widget-text-editor\" data-id=\"aefc7b4\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h5>Optimisation de la formulation :<\/h5><h4>Stabilisants et excipients :<\/h4><p>L\u2019ajout de stabilisants, tels que des sucres, des polyols ou des tensioactifs, peut aider \u00e0 pr\u00e9venir l\u2019agr\u00e9gation en stabilisant la structure prot\u00e9ique et en r\u00e9duisant les interactions intermol\u00e9culaires.<\/p><p><a href=\"https:\/\/pfanstiehl.com\/fr\/categorie-produit\/saccharose-fr\/\">Pfanstiehl HPLE-LM<sup>TM<\/sup> Saccharose<\/a><br \/><a href=\"https:\/\/pfanstiehl.com\/fr\/categorie-produit\/trehalose-fr\/\">Pfanstiehl HPLE-LM<sup>TM<\/sup> Tr\u00e9halose<\/a><br \/><a href=\"https:\/\/pfanstiehl.com\/fr\/categorie-produit\/maltose-fr\/\">Pfanstiehl HPLE-LM<sup>TM<\/sup> Maltose<\/a><br \/><a href=\"https:\/\/pfanstiehl.com\/fr\/categorie-produit\/d-mannitol-fr\/\">Pfanstiehl HPLE-LM<sup>TM<\/sup> Mannitol<\/a><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-637f0104 e-flex e-con-boxed e-con e-parent\" data-id=\"637f0104\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-70523d93 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"70523d93\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-573963b e-flex e-con-boxed e-con e-parent\" data-id=\"573963b\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4af7bf5 solutions_links_margin elementor-widget elementor-widget-text-editor\" data-id=\"4af7bf5\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h4>Syst\u00e8mes tampons :<\/h4><p>Une s\u00e9lection appropri\u00e9e des syst\u00e8mes tampons peut aider \u00e0 maintenir la stabilit\u00e9 et la solubilit\u00e9 de la prot\u00e9ine. Le maintien du pH optimal pour une prot\u00e9ine particuli\u00e8re est crucial.<\/p><p><a href=\"https:\/\/pfanstiehl.com\/fr\/categorie-produit\/tris-base-fr\/\">Pfanstiehl HPLE-LM<sup>TM<\/sup> TRIS Base<\/a><br \/><a href=\"https:\/\/pfanstiehl.com\/fr\/categorie-produit\/tris-hcl-fr\/\">Pfanstiehl HPLE-LM<sup>TM<\/sup> Tris HCL<\/a><br \/><a href=\"https:\/\/pfanstiehl.com\/fr\/categorie-produit\/succinate-de-sodium-hexahydrate\/\">Pfanstiehl HPLE-LM<sup>TM<\/sup> Succinate de sodium<\/a><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-4da3a94d e-flex e-con-boxed e-con e-parent\" data-id=\"4da3a94d\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-75791f76 elementor-widget elementor-widget-text-editor\" data-id=\"75791f76\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Depuis plus de 100 ans, Pfanstiehl fabrique des excipients, des stabilisants et des composants tampons de qualit\u00e9 injectable cGMP qui garantissent une grande puret\u00e9 et une faible teneur en endotoxines. Nos composants sont utilis\u00e9s dans la majorit\u00e9 des produits pharmaceutiques les plus vendus au monde et nous continuons \u00e0 cro\u00eetre chaque ann\u00e9e.  <\/p>\n<\/p>\n<p>Nos clients savent que la combinaison de l\u2019assistance technique prim\u00e9e de Pfanstiehl et des composants cGMP de haute puret\u00e9 \u00e0 faible teneur en endotoxines contribuera \u00e0 assurer une meilleure coh\u00e9rence d\u2019un lot \u00e0 l\u2019autre et \u00e0 r\u00e9duire le risque d\u2019\u00e9chec de la fabrication de votre produit th\u00e9rapeutique.<\/p>\n<\/p>\n<p>Si vous avez un produit biologique ou un vaccin prot\u00e9ique qui n\u00e9cessite un d\u00e9veloppement de formulation pour r\u00e9duire l\u2019agr\u00e9gation, veuillez nous contacter et nous serons heureux de discuter de la mani\u00e8re dont nous pouvons travailler ensemble pour rendre votre produit de la plus haute qualit\u00e9 possible.<\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-62bccdf6 elementor-widget elementor-widget-button\" data-id=\"62bccdf6\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/pfanstiehl.com\/fr\/contactez-nous\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Contactez-nous<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-914e99c e-con-full right_fixed_btn e-flex e-con e-parent\" data-id=\"914e99c\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f49572b fixed_desktop_btn elementor-widget elementor-widget-button\" data-id=\"f49572b\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/pfanstiehl.com\/fr\/contactez-nous\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Contactez-nous<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-28fc589 fixed_mobile_btn elementor-widget elementor-widget-button\" data-id=\"28fc589\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/pfanstiehl.com\/fr\/contactez-nous\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-far-envelope\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M464 64H48C21.49 64 0 85.49 0 112v288c0 26.51 21.49 48 48 48h416c26.51 0 48-21.49 48-48V112c0-26.51-21.49-48-48-48zm0 48v40.805c-22.422 18.259-58.168 46.651-134.587 106.49-16.841 13.247-50.201 45.072-73.413 44.701-23.208.375-56.579-31.459-73.413-44.701C106.18 199.465 70.425 171.067 48 152.805V112h416zM48 400V214.398c22.914 18.251 55.409 43.862 104.938 82.646 21.857 17.205 60.134 55.186 103.062 54.955 42.717.231 80.509-37.199 103.053-54.947 49.528-38.783 82.032-64.401 104.947-82.653V400H48z\"><\/path><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"featured_media":0,"menu_order":0,"template":"elementor_header_footer","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_uf_show_specific_survey":0,"_uf_disable_surveys":false},"class_list":["post-4937","solutions","type-solutions","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.2 - 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