{"id":4930,"date":"2024-06-03T05:53:18","date_gmt":"2024-06-03T05:53:18","guid":{"rendered":"https:\/\/pfanstiehl.com\/solutions\/attenuation-de-la-degradation-du-polysorbate\/"},"modified":"2024-07-08T06:07:20","modified_gmt":"2024-07-08T06:07:20","slug":"attenuation-de-la-degradation-du-polysorbate","status":"publish","type":"solutions","link":"https:\/\/pfanstiehl.com\/fr\/solutions\/attenuation-de-la-degradation-du-polysorbate\/","title":{"rendered":"Att\u00e9nuation de la d\u00e9gradation du polysorbate"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"4930\" class=\"elementor elementor-4930 elementor-1679\" data-elementor-post-type=\"solutions\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3c4dd17b e-flex e-con-boxed e-con e-parent\" data-id=\"3c4dd17b\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-2a73dd8c e-flex e-con-boxed e-con e-child\" data-id=\"2a73dd8c\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4152c960 elementor-widget elementor-widget-heading\" data-id=\"4152c960\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.23.0 - 05-08-2024 *\/\n.elementor-heading-title{padding:0;margin:0;line-height:1}.elementor-widget-heading .elementor-heading-title[class*=elementor-size-]>a{color:inherit;font-size:inherit;line-height:inherit}.elementor-widget-heading .elementor-heading-title.elementor-size-small{font-size:15px}.elementor-widget-heading .elementor-heading-title.elementor-size-medium{font-size:19px}.elementor-widget-heading .elementor-heading-title.elementor-size-large{font-size:29px}.elementor-widget-heading .elementor-heading-title.elementor-size-xl{font-size:39px}.elementor-widget-heading .elementor-heading-title.elementor-size-xxl{font-size:59px}<\/style><h1 class=\"elementor-heading-title elementor-size-default\">Solutions Pfanstiehl pour r\u00e9duire la d\u00e9gradation des tensioactifs dans les formulations biologiques<\/h1>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-424f17af elementor-widget elementor-widget-text-editor\" data-id=\"424f17af\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.23.0 - 05-08-2024 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#69727d;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#69727d;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t<p>Les tensioactifs sont des composants essentiels dans les formulations pharmaceutiques, en particulier dans les \u00e9mulsions, les suspensions et certaines formes posologiques solides. Ils r\u00e9duisent la tension superficielle entre les diff\u00e9rentes phases, aidant \u00e0 la solubilisation, \u00e0 la stabilisation et \u00e0 la dispersion des ingr\u00e9dients pharmaceutiques actifs (API). Cependant, la pr\u00e9sence de m\u00e9taux traces peut avoir un impact significatif sur la stabilit\u00e9 et la d\u00e9gradation des tensioactifs, affectant ainsi la stabilit\u00e9 et l\u2019efficacit\u00e9 globales du produit pharmaceutique.<\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-145f063d e-flex e-con-boxed e-con e-child\" data-id=\"145f063d\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-12208a2c elementor-widget elementor-widget-image\" data-id=\"12208a2c\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.23.0 - 05-08-2024 *\/\n.elementor-widget-image{text-align:center}.elementor-widget-image a{display:inline-block}.elementor-widget-image a img[src$=\".svg\"]{width:48px}.elementor-widget-image img{vertical-align:middle;display:inline-block}<\/style>\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"800\" height=\"450\" src=\"https:\/\/pfanstiehl.com\/wp-content\/uploads\/2024\/06\/sol-1024x576.jpeg\" class=\"attachment-large size-large wp-image-3481\" alt=\"Monoclonal Antibody in final formulation buffer with polysorbate 80\" srcset=\"https:\/\/pfanstiehl.com\/wp-content\/uploads\/2024\/06\/sol-1024x576.jpeg 1024w, https:\/\/pfanstiehl.com\/wp-content\/uploads\/2024\/06\/sol-300x169.jpeg 300w, https:\/\/pfanstiehl.com\/wp-content\/uploads\/2024\/06\/sol-768x432.jpeg 768w, https:\/\/pfanstiehl.com\/wp-content\/uploads\/2024\/06\/sol-1536x864.jpeg 1536w, https:\/\/pfanstiehl.com\/wp-content\/uploads\/2024\/06\/sol-2048x1152.jpeg 2048w, https:\/\/pfanstiehl.com\/wp-content\/uploads\/2024\/06\/sol-600x338.jpeg 600w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7df42d2 e-flex e-con-boxed e-con e-parent\" data-id=\"7df42d2\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-56ee037 elementor-widget elementor-widget-heading\" data-id=\"56ee037\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">M\u00e9canismes de d\u00e9gradation des tensioactifs induits par les traces des m\u00e9taux<\/h3>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-76b9351 e-con-full e-flex e-con e-child\" data-id=\"76b9351\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-ee9d5cf e-flex e-con-boxed e-con e-child\" data-id=\"ee9d5cf\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ebf8ad7 elementor-widget elementor-widget-text-editor\" data-id=\"ebf8ad7\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h4>D\u00e9gradation catalytique par les esp\u00e8ces r\u00e9actives de l\u2019oxyg\u00e8ne :<\/h4>\n<p>Les m\u00e9taux traces tels que le fer (Fe), le cuivre (Cu) et le mangan\u00e8se (Mn) peuvent catalyser la formation d\u2019esp\u00e8ces r\u00e9actives de l\u2019oxyg\u00e8ne (ROS), y compris les radicaux hydroxyles (\u2022OH) et les anions superoxydes (O2\u2022\u2212). Ces ROS sont tr\u00e8s r\u00e9actifs et peuvent initier la d\u00e9gradation oxydative des tensioactifs. Par exemple, les ions fer peuvent participer \u00e0 des r\u00e9actions de type Fenton pour g\u00e9n\u00e9rer des radicaux hydroxyles :<\/p>\n<\/p>\n<p>Fe2++H2O2\u2192Fe3++\u22c5OH+OH\u2212Fe2++H2O2\u2192Fe3++\u22c5OH+OH\u2212<\/p>\n<\/p>\n<p>Les radicaux hydroxyles r\u00e9actifs entra\u00eenent la d\u00e9gradation induite par l\u2019oxydation des tensioactifs comme le polysorbate 80 (PS80), compromettant leur fonctionnalit\u00e9 et leur stabilit\u00e9.<\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6566ab8 e-flex e-con-boxed e-con e-child\" data-id=\"6566ab8\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a47c391 elementor-widget elementor-widget-text-editor\" data-id=\"a47c391\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h4>Formation du complexe m\u00e9tal-tensioactif :<\/h4>\n<p>Les m\u00e9taux traces peuvent se lier directement aux mol\u00e9cules de tensioactif, formant des complexes qui modifient leurs propri\u00e9t\u00e9s physiques et chimiques, telles que la solubilit\u00e9 et l\u2019activit\u00e9 de surface. Cette liaison peut r\u00e9duire l\u2019efficacit\u00e9 du tensioactif \u00e0 abaisser la tension superficielle et \u00e0 stabiliser les \u00e9mulsions ou les suspensions.<\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ac6a38b elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"ac6a38b\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.23.0 - 05-08-2024 *\/\n.elementor-widget-divider{--divider-border-style:none;--divider-border-width:1px;--divider-color:#0c0d0e;--divider-icon-size:20px;--divider-element-spacing:10px;--divider-pattern-height:24px;--divider-pattern-size:20px;--divider-pattern-url:none;--divider-pattern-repeat:repeat-x}.elementor-widget-divider .elementor-divider{display:flex}.elementor-widget-divider .elementor-divider__text{font-size:15px;line-height:1;max-width:95%}.elementor-widget-divider .elementor-divider__element{margin:0 var(--divider-element-spacing);flex-shrink:0}.elementor-widget-divider .elementor-icon{font-size:var(--divider-icon-size)}.elementor-widget-divider .elementor-divider-separator{display:flex;margin:0;direction:ltr}.elementor-widget-divider--view-line_icon .elementor-divider-separator,.elementor-widget-divider--view-line_text .elementor-divider-separator{align-items:center}.elementor-widget-divider--view-line_icon .elementor-divider-separator:after,.elementor-widget-divider--view-line_icon .elementor-divider-separator:before,.elementor-widget-divider--view-line_text .elementor-divider-separator:after,.elementor-widget-divider--view-line_text .elementor-divider-separator:before{display:block;content:\"\";border-block-end:0;flex-grow:1;border-block-start:var(--divider-border-width) var(--divider-border-style) var(--divider-color)}.elementor-widget-divider--element-align-left .elementor-divider .elementor-divider-separator>.elementor-divider__svg:first-of-type{flex-grow:0;flex-shrink:100}.elementor-widget-divider--element-align-left .elementor-divider-separator:before{content:none}.elementor-widget-divider--element-align-left .elementor-divider__element{margin-left:0}.elementor-widget-divider--element-align-right .elementor-divider .elementor-divider-separator>.elementor-divider__svg:last-of-type{flex-grow:0;flex-shrink:100}.elementor-widget-divider--element-align-right .elementor-divider-separator:after{content:none}.elementor-widget-divider--element-align-right .elementor-divider__element{margin-right:0}.elementor-widget-divider--element-align-start .elementor-divider .elementor-divider-separator>.elementor-divider__svg:first-of-type{flex-grow:0;flex-shrink:100}.elementor-widget-divider--element-align-start .elementor-divider-separator:before{content:none}.elementor-widget-divider--element-align-start .elementor-divider__element{margin-inline-start:0}.elementor-widget-divider--element-align-end .elementor-divider .elementor-divider-separator>.elementor-divider__svg:last-of-type{flex-grow:0;flex-shrink:100}.elementor-widget-divider--element-align-end .elementor-divider-separator:after{content:none}.elementor-widget-divider--element-align-end .elementor-divider__element{margin-inline-end:0}.elementor-widget-divider:not(.elementor-widget-divider--view-line_text):not(.elementor-widget-divider--view-line_icon) .elementor-divider-separator{border-block-start:var(--divider-border-width) var(--divider-border-style) var(--divider-color)}.elementor-widget-divider--separator-type-pattern{--divider-border-style:none}.elementor-widget-divider--separator-type-pattern.elementor-widget-divider--view-line .elementor-divider-separator,.elementor-widget-divider--separator-type-pattern:not(.elementor-widget-divider--view-line) .elementor-divider-separator:after,.elementor-widget-divider--separator-type-pattern:not(.elementor-widget-divider--view-line) .elementor-divider-separator:before,.elementor-widget-divider--separator-type-pattern:not([class*=elementor-widget-divider--view]) .elementor-divider-separator{width:100%;min-height:var(--divider-pattern-height);-webkit-mask-size:var(--divider-pattern-size) 100%;mask-size:var(--divider-pattern-size) 100%;-webkit-mask-repeat:var(--divider-pattern-repeat);mask-repeat:var(--divider-pattern-repeat);background-color:var(--divider-color);-webkit-mask-image:var(--divider-pattern-url);mask-image:var(--divider-pattern-url)}.elementor-widget-divider--no-spacing{--divider-pattern-size:auto}.elementor-widget-divider--bg-round{--divider-pattern-repeat:round}.rtl .elementor-widget-divider .elementor-divider__text{direction:rtl}.e-con-inner>.elementor-widget-divider,.e-con>.elementor-widget-divider{width:var(--container-widget-width,100%);--flex-grow:var(--container-widget-flex-grow)}<\/style>\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-09889a0 e-flex e-con-boxed e-con e-parent\" data-id=\"09889a0\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7b2c112 elementor-widget elementor-widget-text-editor\" data-id=\"7b2c112\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h3>Impact des traces des m\u00e9taux sur la stabilit\u00e9 des prot\u00e9ines et l\u2019efficacit\u00e9 th\u00e9rapeutique<\/h3>\n<p>La pr\u00e9sence de m\u00e9taux traces affecte non seulement les tensioactifs, mais a \u00e9galement des implications importantes sur la stabilit\u00e9 des prot\u00e9ines et l\u2019efficacit\u00e9 th\u00e9rapeutique des substances m\u00e9dicamenteuses (DS) et des produits pharmaceutiques (DP) :<\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-63f5208 e-con-full e-flex e-con e-child\" data-id=\"63f5208\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-2a309ac e-flex e-con-boxed e-con e-child\" data-id=\"2a309ac\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a53b53d elementor-widget elementor-widget-text-editor\" data-id=\"a53b53d\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h4>Fragmentation des prot\u00e9ines :<\/h4>\n<p>Le fer (Fe), en particulier, peut induire la fragmentation des prot\u00e9ines par des m\u00e9canismes oxydatifs. Les ROS g\u00e9n\u00e9r\u00e9s peuvent attaquer les mol\u00e9cules de prot\u00e9ines, entra\u00eenant une fragmentation et une d\u00e9gradation. Cela peut affecter consid\u00e9rablement la stabilit\u00e9 et l\u2019efficacit\u00e9 th\u00e9rapeutique des m\u00e9dicaments \u00e0 base de prot\u00e9ines.<\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-5b5b09a e-flex e-con-boxed e-con e-child\" data-id=\"5b5b09a\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-089a5be elementor-widget elementor-widget-text-editor\" data-id=\"089a5be\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h4>Efficacit\u00e9 th\u00e9rapeutique r\u00e9duite :<\/h4>\n<p>La d\u00e9gradation des tensioactifs et la fragmentation des prot\u00e9ines compromettent la stabilit\u00e9 et l\u2019int\u00e9grit\u00e9 des formulations pharmaceutiques. Cela peut entra\u00eener une r\u00e9duction de l\u2019efficacit\u00e9 th\u00e9rapeutique et des probl\u00e8mes potentiels d\u2019innocuit\u00e9, car les composants d\u00e9grad\u00e9s peuvent pr\u00e9senter une activit\u00e9 biologique alt\u00e9r\u00e9e ou diminu\u00e9e.<\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-15dd608 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"15dd608\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3aee7d4 e-flex e-con-boxed e-con e-parent\" data-id=\"3aee7d4\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-21dbc9f elementor-widget elementor-widget-text-editor\" data-id=\"21dbc9f\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h3>Importance d\u2019utiliser les excipients les plus purs<\/h3>\n<p>Compte tenu des effets ind\u00e9sirables potentiels des m\u00e9taux traces sur les tensioactifs et les prot\u00e9ines, il est crucial d\u2019utiliser des excipients (ingr\u00e9dients inactifs) de la plus haute puret\u00e9 dans les formulations de produits biologiques :<\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-af39dd6 e-con-full e-flex e-con e-child\" data-id=\"af39dd6\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-0f13c90 e-flex e-con-boxed e-con e-child\" data-id=\"0f13c90\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ec0d5c9 elementor-widget elementor-widget-text-editor\" data-id=\"ec0d5c9\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h4>Stabilit\u00e9 de la formulation :<\/h4>\n<p>Les excipients purs minimisent le risque de d\u00e9gradation induite par les m\u00e9taux traces, assurant la stabilit\u00e9 \u00e0 long terme de la formulation. Ceci est particuli\u00e8rement important pour les produits \u00e0 dur\u00e9e de conservation prolong\u00e9e ou ceux expos\u00e9s \u00e0 des conditions environnementales variables<\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-d56f866 e-flex e-con-boxed e-con e-child\" data-id=\"d56f866\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2655903 elementor-widget elementor-widget-text-editor\" data-id=\"2655903\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h4>Efficacit\u00e9 et innocuit\u00e9 :<\/h4>\n<p>Les impuret\u00e9s contenues dans les excipients, y compris les m\u00e9taux traces, peuvent interagir avec les principes actifs, ce qui affecte l\u2019efficacit\u00e9 th\u00e9rapeutique et l\u2019innocuit\u00e9 du produit. Les excipients de haute puret\u00e9 aident \u00e0 maintenir le profil de performance et de s\u00e9curit\u00e9 pr\u00e9vu du m\u00e9dicament.<\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-15cb6d3 e-con-full e-flex e-con e-child\" data-id=\"15cb6d3\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-8e78762 e-flex e-con-boxed e-con e-child\" data-id=\"8e78762\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-0280a53 elementor-widget elementor-widget-text-editor\" data-id=\"0280a53\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h4>Conformit\u00e9 r\u00e9glementaire :<\/h4>\n<p>Les produits pharmaceutiques doivent r\u00e9pondre \u00e0 des normes r\u00e9glementaires strictes en mati\u00e8re de qualit\u00e9 et de puret\u00e9. L\u2019utilisation d\u2019excipients de haute puret\u00e9 permet de respecter ces normes et d\u2019\u00e9viter des rappels ou des rejets co\u00fbteux dus \u00e0 des probl\u00e8mes de stabilit\u00e9 ou de contamination.<\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ad20904 e-flex e-con-boxed e-con e-child\" data-id=\"ad20904\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c41324d elementor-widget elementor-widget-text-editor\" data-id=\"c41324d\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h4>Performances constantes :<\/h4>\n<p>Garantir la puret\u00e9 des excipients conduit \u00e0 des r\u00e9sultats de fabrication et \u00e0 des performances de produit plus coh\u00e9rents. Les variations des niveaux de m\u00e9taux traces peuvent entra\u00eener une variabilit\u00e9 d\u2019un lot \u00e0 l\u2019autre, affectant la fiabilit\u00e9 du produit pharmaceutique.<\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d0f4184 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"d0f4184\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-03e24c2 e-flex e-con-boxed e-con e-parent\" data-id=\"03e24c2\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7cacc5a elementor-widget elementor-widget-text-editor\" data-id=\"7cacc5a\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h3>Que peut faire Pfanstiehl pour aider ?<\/h3>\n<p>Les scientifiques technico-commerciaux de Pfanstiehl peuvent discuter avec vous pour comprendre vos d\u00e9fis et vous fournir des conseils bas\u00e9s sur l\u2019exp\u00e9rience et les revues de litt\u00e9rature pour r\u00e9duire la d\u00e9gradation des tensioactifs et stabiliser la structure et l\u2019activit\u00e9 biologique de votre prot\u00e9ine th\u00e9rapeutique.<\/p>\n<\/p>\n<p>Laissez-nous vous aider \u00e0 rassembler quelques id\u00e9es pour :<\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7b380ed solutions_content_box e-flex e-con-boxed e-con e-child\" data-id=\"7b380ed\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-7875f01 e-flex e-con-boxed e-con e-child\" data-id=\"7875f01\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-bb0e317 elementor-widget elementor-widget-text-editor\" data-id=\"bb0e317\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h4>Utilisation de ch\u00e9lateurs m\u00e9talliques :<\/h4><p>en combinaison avec d\u2019autres excipients de haute puret\u00e9, les acides amin\u00e9s Pfanstiehl \u00e0 faible teneur en m\u00e9taux comme la L-m\u00e9thionine Pfanstiehl, \u00e0 faible concentration, peuvent agir comme ch\u00e9lateurs et s\u00e9questrer les m\u00e9taux traces, r\u00e9duisant ainsi le risque de d\u00e9gradation des tensioactifs.<\/p><p><a href=\"https:\/\/pfanstiehl.com\/fr\/categorie-produit\/methionine\/\">Pfanstiehl HPLE-LM<sup>TM<\/sup> L-m\u00e9thionine<\/a><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-078d9f8 e-flex e-con-boxed e-con e-child\" data-id=\"078d9f8\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8dba9c6 elementor-widget elementor-widget-text-editor\" data-id=\"8dba9c6\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h4>Optimisation des syst\u00e8mes tampons :<\/h4><p>L\u2019ajustement du pH et de la composition du syst\u00e8me tampon peut am\u00e9liorer la solubilit\u00e9 et la stabilit\u00e9, ce qui est crucial pour les formulations \u00e0 forte concentration.<\/p><p><a href=\"https:\/\/pfanstiehl.com\/fr\/categorie-produit\/tris-base-fr\/\">Pfanstiehl HPLE-LM<sup>TM<\/sup> TRIS Base<\/a><br \/><a href=\"https:\/\/pfanstiehl.com\/fr\/categorie-produit\/tris-hcl-fr\/\">Pfanstiehl HPLE-LM<sup>TM<\/sup> Tris HCL<\/a><br \/><a href=\"https:\/\/pfanstiehl.com\/fr\/categorie-produit\/sodium-gluconate-fr\/\">Pfanstiehl HPLE-LM<sup>TM<\/sup> Gluconate de sodium<\/a><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-9be0b22 e-flex e-con-boxed e-con e-child\" data-id=\"9be0b22\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c27379a elementor-widget elementor-widget-text-editor\" data-id=\"c27379a\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h4>Utilisation d\u2019excipients et d\u2019agents stabilisants de la plus haute puret\u00e9 :<\/h4><p>L\u2019incorporation de la combinaison d\u2019excipients de la plus haute puret\u00e9 et des m\u00e9taux les plus bas, tels que le saccharose Pfanstiehl et la L-histidine Pfanstiehl, peut r\u00e9duire consid\u00e9rablement le risque de d\u00e9gradation des tensioactifs.<\/p><p><a href=\"https:\/\/pfanstiehl.com\/fr\/categorie-produit\/saccharose-fr\/\">Pfanstiehl HPLE-LM<sup>TM<\/sup> Saccharose<\/a><br \/><a href=\"https:\/\/pfanstiehl.com\/fr\/categorie-produit\/histidine-fr\/\">Pfanstiehl HPLE-LM<sup>TM<\/sup> L-histidine<\/a><br \/><a href=\"https:\/\/pfanstiehl.com\/fr\/categorie-produit\/histidine-hcl-fr\/\">Pfanstiehl HPLE-LM<sup>TM<\/sup> L-Histidine HCL<\/a><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d5ca35c elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"d5ca35c\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1cff2a1d e-flex e-con-boxed e-con e-parent\" data-id=\"1cff2a1d\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3b2b6005 elementor-widget elementor-widget-text-editor\" data-id=\"3b2b6005\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><strong>Depuis plus de 100 ans, Pfanstiehl fabrique des excipients, des stabilisants et des composants tampons de qualit\u00e9 injectable cGMP qui garantissent une grande puret\u00e9, une faible teneur en endotoxines et une faible teneur en m\u00e9taux de transition.<\/strong><\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-27a084d elementor-widget elementor-widget-text-editor\" data-id=\"27a084d\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Les composants Pfanstiehl sont utilis\u00e9s dans la majorit\u00e9 des produits biopharmaceutiques les plus vendus au monde et nous continuons \u00e0 cro\u00eetre chaque ann\u00e9e.<\/p>\n<\/p>\n<p>Nos clients savent que la combinaison de l\u2019assistance technique prim\u00e9e de Pfanstiehl et des excipients cGMP de haute puret\u00e9 \u00e0 faible teneur en endotoxines, des acides amin\u00e9s et des sels tampons contribuera \u00e0 assurer une meilleure coh\u00e9rence d\u2019un lot \u00e0 l\u2019autre et \u00e0 r\u00e9duire le risque d\u2019\u00e9chec de la fabrication de votre produit th\u00e9rapeutique.<\/p>\n<\/p>\n<p>Si vous avez un produit biologique ou un vaccin prot\u00e9ique qui n\u00e9cessite un surfactant dans la formulation finale, veuillez nous contacter et nous serons heureux de discuter de la fa\u00e7on dont nous pouvons travailler ensemble pour r\u00e9duire consid\u00e9rablement le risque de d\u00e9gradation du surfactant.<\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-19d93b45 elementor-widget elementor-widget-button\" data-id=\"19d93b45\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/pfanstiehl.com\/fr\/contactez-nous\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Contactez-nous<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-5a3c496b e-con-full right_fixed_btn e-flex e-con e-parent\" data-id=\"5a3c496b\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7c5cf5f8 fixed_desktop_btn elementor-widget elementor-widget-button\" data-id=\"7c5cf5f8\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/pfanstiehl.com\/fr\/contactez-nous\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Contactez-nous<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-60f428e5 fixed_mobile_btn elementor-widget elementor-widget-button\" data-id=\"60f428e5\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/pfanstiehl.com\/fr\/contactez-nous\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-far-envelope\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M464 64H48C21.49 64 0 85.49 0 112v288c0 26.51 21.49 48 48 48h416c26.51 0 48-21.49 48-48V112c0-26.51-21.49-48-48-48zm0 48v40.805c-22.422 18.259-58.168 46.651-134.587 106.49-16.841 13.247-50.201 45.072-73.413 44.701-23.208.375-56.579-31.459-73.413-44.701C106.18 199.465 70.425 171.067 48 152.805V112h416zM48 400V214.398c22.914 18.251 55.409 43.862 104.938 82.646 21.857 17.205 60.134 55.186 103.062 54.955 42.717.231 80.509-37.199 103.053-54.947 49.528-38.783 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href=\"https:\/\/pfanstiehl.com\/fr\/solutions\/attenuation-de-la-degradation-du-polysorbate\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Att\u00e9nuation de la d\u00e9gradation du polysorbate - Pfanstiehl\" \/>\n<meta property=\"og:description\" content=\"Solutions Pfanstiehl pour r\u00e9duire la d\u00e9gradation des tensioactifs dans les formulations biologiques Les tensioactifs sont des composants essentiels dans les formulations pharmaceutiques, en particulier dans les \u00e9mulsions, les suspensions et certaines formes posologiques solides. 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