{"id":8161,"date":"2024-08-08T10:33:56","date_gmt":"2024-08-08T10:33:56","guid":{"rendered":"https:\/\/pfanstiehl.com\/solutions\/vaccine-biologic-stabilization-copy\/"},"modified":"2025-10-02T22:51:47","modified_gmt":"2025-10-02T22:51:47","slug":"bispecific-trispecific-antibody-formulations","status":"publish","type":"solutions","link":"https:\/\/pfanstiehl.com\/en\/solutions\/bispecific-trispecific-antibody-formulations\/","title":{"rendered":"Bispecific &#038; Trispecific Antibody Formulations"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"8161\" class=\"elementor elementor-8161\" data-elementor-post-type=\"solutions\">\n\t\t\t\t<div class=\"elementor-element elementor-element-47c57ccb e-flex e-con-boxed e-con e-parent\" data-id=\"47c57ccb\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-74be739a e-flex e-con-boxed e-con e-child\" data-id=\"74be739a\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-61d9515c elementor-widget elementor-widget-heading\" data-id=\"61d9515c\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.23.0 - 05-08-2024 *\/\n.elementor-heading-title{padding:0;margin:0;line-height:1}.elementor-widget-heading .elementor-heading-title[class*=elementor-size-]>a{color:inherit;font-size:inherit;line-height:inherit}.elementor-widget-heading .elementor-heading-title.elementor-size-small{font-size:15px}.elementor-widget-heading .elementor-heading-title.elementor-size-medium{font-size:19px}.elementor-widget-heading .elementor-heading-title.elementor-size-large{font-size:29px}.elementor-widget-heading .elementor-heading-title.elementor-size-xl{font-size:39px}.elementor-widget-heading .elementor-heading-title.elementor-size-xxl{font-size:59px}<\/style><h1 class=\"elementor-heading-title elementor-size-default\">Pfanstiehl Excipient Solutions for Complex Bispecific or Trispecific Antibody Formulations<\/h1>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-40ed537b elementor-widget elementor-widget-text-editor\" data-id=\"40ed537b\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.23.0 - 05-08-2024 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#69727d;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#69727d;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t<p>Stabilizing bispecific or trispecific monoclonal antibodies (mAbs) presents several challenges due to their complex structures and the increased likelihood of instability compared to traditional monoclonal antibodies.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2e42849a e-flex e-con-boxed e-con e-child\" data-id=\"2e42849a\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1480b180 elementor-widget elementor-widget-image\" data-id=\"1480b180\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.23.0 - 05-08-2024 *\/\n.elementor-widget-image{text-align:center}.elementor-widget-image a{display:inline-block}.elementor-widget-image a img[src$=\".svg\"]{width:48px}.elementor-widget-image img{vertical-align:middle;display:inline-block}<\/style>\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"800\" height=\"539\" src=\"https:\/\/pfanstiehl.com\/wp-content\/uploads\/2024\/08\/bispecific-trispecific-antibody-formulations-1024x690.webp\" class=\"attachment-large size-large wp-image-8270\" alt=\"Bispecific Monoclonal Antibody in Final Formulation Buffer\" srcset=\"https:\/\/pfanstiehl.com\/wp-content\/uploads\/2024\/08\/bispecific-trispecific-antibody-formulations-1024x690.webp 1024w, https:\/\/pfanstiehl.com\/wp-content\/uploads\/2024\/08\/bispecific-trispecific-antibody-formulations-300x202.webp 300w, https:\/\/pfanstiehl.com\/wp-content\/uploads\/2024\/08\/bispecific-trispecific-antibody-formulations-768x517.webp 768w, https:\/\/pfanstiehl.com\/wp-content\/uploads\/2024\/08\/bispecific-trispecific-antibody-formulations-1536x1035.webp 1536w, https:\/\/pfanstiehl.com\/wp-content\/uploads\/2024\/08\/bispecific-trispecific-antibody-formulations-2048x1380.webp 2048w, https:\/\/pfanstiehl.com\/wp-content\/uploads\/2024\/08\/bispecific-trispecific-antibody-formulations-600x404.webp 600w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-f1dfcb7 e-flex e-con-boxed e-con e-parent\" data-id=\"f1dfcb7\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9aec0e4 elementor-widget elementor-widget-heading\" data-id=\"9aec0e4\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Challenges with Stabilizing Bispecific or Trispecific mAbs<\/h3>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1ff841d e-con-full e-flex e-con e-child\" data-id=\"1ff841d\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-dcb612a e-flex e-con-boxed e-con e-child\" data-id=\"dcb612a\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4399fd0 elementor-widget elementor-widget-text-editor\" data-id=\"4399fd0\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h4>Structural Complexity:<\/h4>\nBispecific and trispecific mAbs have more complex structures compared to traditional mAbs. This complexity can lead to greater instability, as there are more regions that can potentially misfold or aggregate.\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1ba4ed0 e-flex e-con-boxed e-con e-child\" data-id=\"1ba4ed0\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-fd6e674 elementor-widget elementor-widget-text-editor\" data-id=\"fd6e674\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h4>Aggregation:<\/h4>\nThe tendency to aggregate is higher in multi-specific mAbs due to the presence of multiple binding domains. Aggregation can reduce efficacy and increase immunogenicity.\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-329827e e-con-full e-flex e-con e-child\" data-id=\"329827e\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-2c23843 e-flex e-con-boxed e-con e-child\" data-id=\"2c23843\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-0166183 elementor-widget elementor-widget-text-editor\" data-id=\"0166183\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h4>Chemical Instability:<\/h4><p>Multi-specific mAbs are prone to chemical degradation, such as deamidation, oxidation, and hydrolysis. These processes can alter the function and binding affinity of the antibodies.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-607dda9 e-flex e-con-boxed e-con e-child\" data-id=\"607dda9\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-94ec21e elementor-widget elementor-widget-text-editor\" data-id=\"94ec21e\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h4>Physical Instability:<\/h4><p>They may also be more susceptible to physical instability, such as denaturation and precipitation, especially during manufacturing, storage, and transportation.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-aebc7ea e-con-full e-flex e-con e-child\" data-id=\"aebc7ea\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-08d094e e-flex e-con-boxed e-con e-child\" data-id=\"08d094e\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-284a831 elementor-widget elementor-widget-text-editor\" data-id=\"284a831\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h4>Manufacturing Challenges:<\/h4><p>The production process is more complex, requiring precise control over conditions to maintain stability. Any variations can result in instability or loss of functionality.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3782302 e-flex e-con-boxed e-con e-child\" data-id=\"3782302\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-111de5e elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"111de5e\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.23.0 - 05-08-2024 *\/\n.elementor-widget-divider{--divider-border-style:none;--divider-border-width:1px;--divider-color:#0c0d0e;--divider-icon-size:20px;--divider-element-spacing:10px;--divider-pattern-height:24px;--divider-pattern-size:20px;--divider-pattern-url:none;--divider-pattern-repeat:repeat-x}.elementor-widget-divider .elementor-divider{display:flex}.elementor-widget-divider .elementor-divider__text{font-size:15px;line-height:1;max-width:95%}.elementor-widget-divider .elementor-divider__element{margin:0 var(--divider-element-spacing);flex-shrink:0}.elementor-widget-divider .elementor-icon{font-size:var(--divider-icon-size)}.elementor-widget-divider .elementor-divider-separator{display:flex;margin:0;direction:ltr}.elementor-widget-divider--view-line_icon .elementor-divider-separator,.elementor-widget-divider--view-line_text .elementor-divider-separator{align-items:center}.elementor-widget-divider--view-line_icon .elementor-divider-separator:after,.elementor-widget-divider--view-line_icon .elementor-divider-separator:before,.elementor-widget-divider--view-line_text .elementor-divider-separator:after,.elementor-widget-divider--view-line_text .elementor-divider-separator:before{display:block;content:\"\";border-block-end:0;flex-grow:1;border-block-start:var(--divider-border-width) var(--divider-border-style) var(--divider-color)}.elementor-widget-divider--element-align-left .elementor-divider .elementor-divider-separator>.elementor-divider__svg:first-of-type{flex-grow:0;flex-shrink:100}.elementor-widget-divider--element-align-left .elementor-divider-separator:before{content:none}.elementor-widget-divider--element-align-left .elementor-divider__element{margin-left:0}.elementor-widget-divider--element-align-right .elementor-divider .elementor-divider-separator>.elementor-divider__svg:last-of-type{flex-grow:0;flex-shrink:100}.elementor-widget-divider--element-align-right .elementor-divider-separator:after{content:none}.elementor-widget-divider--element-align-right .elementor-divider__element{margin-right:0}.elementor-widget-divider--element-align-start .elementor-divider .elementor-divider-separator>.elementor-divider__svg:first-of-type{flex-grow:0;flex-shrink:100}.elementor-widget-divider--element-align-start .elementor-divider-separator:before{content:none}.elementor-widget-divider--element-align-start .elementor-divider__element{margin-inline-start:0}.elementor-widget-divider--element-align-end .elementor-divider .elementor-divider-separator>.elementor-divider__svg:last-of-type{flex-grow:0;flex-shrink:100}.elementor-widget-divider--element-align-end .elementor-divider-separator:after{content:none}.elementor-widget-divider--element-align-end .elementor-divider__element{margin-inline-end:0}.elementor-widget-divider:not(.elementor-widget-divider--view-line_text):not(.elementor-widget-divider--view-line_icon) .elementor-divider-separator{border-block-start:var(--divider-border-width) var(--divider-border-style) var(--divider-color)}.elementor-widget-divider--separator-type-pattern{--divider-border-style:none}.elementor-widget-divider--separator-type-pattern.elementor-widget-divider--view-line .elementor-divider-separator,.elementor-widget-divider--separator-type-pattern:not(.elementor-widget-divider--view-line) .elementor-divider-separator:after,.elementor-widget-divider--separator-type-pattern:not(.elementor-widget-divider--view-line) .elementor-divider-separator:before,.elementor-widget-divider--separator-type-pattern:not([class*=elementor-widget-divider--view]) .elementor-divider-separator{width:100%;min-height:var(--divider-pattern-height);-webkit-mask-size:var(--divider-pattern-size) 100%;mask-size:var(--divider-pattern-size) 100%;-webkit-mask-repeat:var(--divider-pattern-repeat);mask-repeat:var(--divider-pattern-repeat);background-color:var(--divider-color);-webkit-mask-image:var(--divider-pattern-url);mask-image:var(--divider-pattern-url)}.elementor-widget-divider--no-spacing{--divider-pattern-size:auto}.elementor-widget-divider--bg-round{--divider-pattern-repeat:round}.rtl .elementor-widget-divider .elementor-divider__text{direction:rtl}.e-con-inner>.elementor-widget-divider,.e-con>.elementor-widget-divider{width:var(--container-widget-width,100%);--flex-grow:var(--container-widget-flex-grow)}<\/style>\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-77ed0f1 e-flex e-con-boxed e-con e-parent\" data-id=\"77ed0f1\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6d83ef6 elementor-widget elementor-widget-heading\" data-id=\"6d83ef6\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Excipient Selection for Complex Antibodies is Critical.<\/h3>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cb3725e elementor-widget elementor-widget-text-editor\" data-id=\"cb3725e\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h4>The Following Considerations Should be considered:<\/h4>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2c97206 e-con-full e-flex e-con e-child\" data-id=\"2c97206\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-99094db e-flex e-con-boxed e-con e-child\" data-id=\"99094db\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e764bca elementor-widget elementor-widget-text-editor\" data-id=\"e764bca\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h4>Compatibility:<\/h4><p>Excipients must be compatible with the mAbs and not interact adversely. This requires thorough screening and testing during formulation development.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-318cb69 e-flex e-con-boxed e-con e-child\" data-id=\"318cb69\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d880541 elementor-widget elementor-widget-text-editor\" data-id=\"d880541\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h4>Concentration:<\/h4><p>The concentration of excipients must be optimized to achieve the desired stability without causing adverse effects.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-338cddb e-con-full e-flex e-con e-child\" data-id=\"338cddb\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-2427d19 e-flex e-con-boxed e-con e-child\" data-id=\"2427d19\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1389260 elementor-widget elementor-widget-text-editor\" data-id=\"1389260\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h4>Regulatory Compliance:<\/h4><p>Excipients should be Generally Recognized As Safe (GRAS) and comply with regulatory standards for pharmaceutical formulations.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-e46655a e-flex e-con-boxed e-con e-child\" data-id=\"e46655a\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-bae7029 elementor-widget elementor-widget-text-editor\" data-id=\"bae7029\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h4>Stability Studies:<\/h4><p>Long-term stability studies under various conditions (temperature, humidity, light exposure) are necessary to ensure that the selected excipients provide adequate protection throughout the product\u2019s shelf life.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1f64bd6 elementor-widget elementor-widget-text-editor\" data-id=\"1f64bd6\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>\u00a0<\/p><p>Stability and shelf life of bispecific or trispecific monoclonal antibodies are significantly influenced by the careful selection of excipients.<\/p><p>These excipients help mitigate the inherent instability challenges posed by the complex structure of multi-specific mAbs, ensuring their efficacy and safety over time<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0b646f4 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"0b646f4\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-4761d847 e-flex e-con-boxed e-con e-parent\" data-id=\"4761d847\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1a76f76c elementor-widget elementor-widget-text-editor\" data-id=\"1a76f76c\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h4>Pfanstiehl High Purity, Low Endotoxin, Low Metals Excipients Can Help<\/h4><p>Pfanstiehl\u2019s Technical Sales Scientists can discuss with you to understand your challenges and provide guidance based on experience and literature reviews to reduce the viscosity and stabilize the structure and biologic activity of your complex antibody.<\/p><p><strong>Let us help put together some ideas for:<\/strong><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-813035a solutions_content_box e-flex e-con-boxed e-con e-child\" data-id=\"813035a\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-c96b560 e-flex e-con-boxed e-con e-child\" data-id=\"c96b560\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-68c14952 elementor-widget elementor-widget-text-editor\" data-id=\"68c14952\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h4>Stabilizing Agents:<\/h4><p>Incorporating stabilizing agents like sugars or polyols can protect proteins from denaturation and aggregation during storage and handling.<\/p><p><a href=\"https:\/\/pfanstiehl.com\/high-purity-ingredients\/sucrose\/\">Pfanstiehl HPLE-LM<sup>TM<\/sup> Sucrose<\/a><br \/><a href=\"https:\/\/pfanstiehl.com\/high-purity-ingredients\/trehalose\/\">Pfanstiehl HPLE-LM<sup>TM<\/sup> Trehalose<\/a><br \/><a href=\"https:\/\/pfanstiehl.com\/high-purity-ingredients\/maltose\/\">Pfanstiehl HPLE-LM<sup>TM<\/sup> Maltose<\/a><br \/><a href=\"https:\/\/pfanstiehl.com\/high-purity-ingredients\/mannitol\/\">Pfanstiehl HPLE-LM<sup>TM<\/sup> Mannitol<\/a><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7122149b e-flex e-con-boxed e-con e-child\" data-id=\"7122149b\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3712f4fb elementor-widget elementor-widget-text-editor\" data-id=\"3712f4fb\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h4>Utilizing Viscosity Reducing Excipients<\/h4><p>Incorporating viscosity-reducing excipients like arginine, sodium chloride, or specific amino acids can mitigate viscosity increases while maintaining stability.<\/p><p><a href=\"https:\/\/pfanstiehl.com\/high-purity-ingredients\/arginine\/\">Pfanstiehl HPLE-LM<\/a><a href=\"https:\/\/pfanstiehl.com\/high-purity-ingredients\/sucrose\/\"><sup>TM<\/sup><\/a><a href=\"https:\/\/pfanstiehl.com\/high-purity-ingredients\/arginine\/\"> L-Arginine<\/a><br \/><a href=\"https:\/\/pfanstiehl.com\/high-purity-ingredients\/arginine-hcl\/\">Pfanstiehl HPLE-LM<\/a><a href=\"https:\/\/pfanstiehl.com\/high-purity-ingredients\/sucrose\/\"><sup>TM<\/sup><\/a><a href=\"https:\/\/pfanstiehl.com\/high-purity-ingredients\/arginine-hcl\/\"> L-Arginine HCL<\/a><br \/><a href=\"https:\/\/pfanstiehl.com\/high-purity-ingredients\/histidine\/\">Pfanstiehl HPLE-LM<\/a><a href=\"https:\/\/pfanstiehl.com\/high-purity-ingredients\/sucrose\/\"><sup>TM<\/sup><\/a><a href=\"https:\/\/pfanstiehl.com\/high-purity-ingredients\/histidine\/\"> L-Histidine<\/a><br \/><a href=\"https:\/\/pfanstiehl.com\/high-purity-ingredients\/histidine-hcl\/\">Pfanstiehl HPLE-LM<\/a><a href=\"https:\/\/pfanstiehl.com\/high-purity-ingredients\/sucrose\/\"><sup>TM<\/sup><\/a><a href=\"https:\/\/pfanstiehl.com\/high-purity-ingredients\/histidine-hcl\/\"> L-Histidine HCL<\/a><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-4c6e431a e-con-full e-flex e-con e-child\" data-id=\"4c6e431a\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-174617ca elementor-widget elementor-widget-text-editor\" data-id=\"174617ca\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h4>Optimizing Buffer Systems:<\/h4><p>Adjusting the buffer system\u2019s pH and composition can enhance solubility and stability, crucial for high concentration formulations.<\/p><p><a href=\"https:\/\/pfanstiehl.com\/high-purity-ingredients\/tris-base\/\">Pfanstiehl HPLE-LM<sup>TM<\/sup> TRIS Base<\/a><br \/><a href=\"https:\/\/pfanstiehl.com\/high-purity-ingredients\/tris-hcl\/\">Pfanstiehl HPLE-LM<sup>TM<\/sup> Tris HCL<\/a><br \/><a href=\"https:\/\/pfanstiehl.com\/high-purity-ingredients\/sodium-succinate-hexahydrate\/\">Pfanstiehl HPLE-LM<sup>TM<\/sup> Sodium Succinate<\/a><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7af15e6 e-flex e-con-boxed e-con e-parent\" data-id=\"7af15e6\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4bdc528e elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"4bdc528e\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7d2a12d7 e-flex e-con-boxed e-con e-parent\" data-id=\"7d2a12d7\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-445166b0 elementor-widget elementor-widget-text-editor\" data-id=\"445166b0\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>For over 100 years, Pfanstiehl has made cGMP Injectable grade excipients, stabilizers, and buffer components that are guaranteed high purity and low endotoxin.\u00a0 Our components are used in the majority of the world\u2019s top selling biopharmaceuticals and we continue to grow every year.<\/p><p>\u00a0<\/p><p>Our customers know that the combination of Pfanstiehl\u2019s award winning technical support and high purity low endotoxin cGMP components will help ensure better consistency from batch to batch and reduce the risk of manufacturing batch failure for your therapeutic.<\/p><p>\u00a0<\/p><p>If you have a complex antibody or protein biologic requiring an excipient solution, please contact us and we will be happy to discuss how we can work together to make your product as high quality as possible.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1f66e08e elementor-widget elementor-widget-button\" data-id=\"1f66e08e\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/pfanstiehl.com\/contact-us\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Contact Us<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div 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