{"id":81,"count":6,"description":"<strong>L-Histidine HCl Excipient GMP<\/strong> is the hydrochloride salt of the naturally occurring amino acid L-histidine and is widely used as a buffering excipient in monoclonal antibody (mAb) formulations. Its imidazole side chain provides effective buffering capacity in the mildly acidic pH range (typically ~5.5\u20136.5) where many antibodies exhibit optimal stability. In mAb formulations, Histidine HCl helps maintain consistent pH during manufacturing, storage, and administration, reducing the risk of protein aggregation, denaturation, and chemical degradation. Because histidine is endogenous and well tolerated, it has an excellent safety profile for parenteral use, and its hydrochloride salt offers high solubility and precise pH control. These properties, combined with broad regulatory acceptance and compatibility with other common excipients, make Histidine HCl a preferred buffer system for modern monoclonal antibody products.","link":"https:\/\/pfanstiehl.com\/en\/high-purity-ingredients\/histidine-hcl\/","name":"L-Histidine HCl","slug":"histidine-hcl","taxonomy":"product_cat","parent":0,"meta":[],"menu_order":0,"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>L-Histidine HCl Excipient GMP BP EP JP ChP - CAS 5934-29-2 - Pfanstiehl<\/title>\n<meta name=\"description\" content=\"L-Histidine HCl Excipient GMP for Highest Purity, Lowest Endotoxin, Lowest Metals amino acid for enhanced biologic formulation buffering and stability\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pfanstiehl.com\/en\/high-purity-ingredients\/histidine-hcl\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"L-Histidine HCl Excipient GMP BP EP JP ChP - CAS 5934-29-2 - Pfanstiehl\" \/>\n<meta property=\"og:description\" content=\"L-Histidine HCl Excipient GMP for Highest Purity, Lowest Endotoxin, Lowest Metals amino acid for enhanced biologic formulation buffering and stability\" \/>\n<meta property=\"og:url\" content=\"https:\/\/pfanstiehl.com\/en\/high-purity-ingredients\/histidine-hcl\/\" \/>\n<meta property=\"og:site_name\" content=\"Pfanstiehl\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"CollectionPage\",\"@id\":\"https:\\\/\\\/pfanstiehl.com\\\/en\\\/high-purity-ingredients\\\/histidine-hcl\\\/\",\"url\":\"https:\\\/\\\/pfanstiehl.com\\\/en\\\/high-purity-ingredients\\\/histidine-hcl\\\/\",\"name\":\"L-Histidine HCl Excipient GMP BP EP JP ChP - CAS 5934-29-2 - Pfanstiehl\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/pfanstiehl.com\\\/en\\\/#website\"},\"description\":\"L-Histidine HCl Excipient GMP for Highest Purity, Lowest Endotoxin, Lowest Metals amino acid for enhanced biologic formulation buffering and stability\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/pfanstiehl.com\\\/en\\\/high-purity-ingredients\\\/histidine-hcl\\\/#breadcrumb\"},\"inLanguage\":\"en-US\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/pfanstiehl.com\\\/en\\\/high-purity-ingredients\\\/histidine-hcl\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/pfanstiehl.com\\\/en\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"L-Histidine HCl\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/pfanstiehl.com\\\/en\\\/#website\",\"url\":\"https:\\\/\\\/pfanstiehl.com\\\/en\\\/\",\"name\":\"Pfanstiehl\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\\\/\\\/pfanstiehl.com\\\/en\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/pfanstiehl.com\\\/en\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/pfanstiehl.com\\\/en\\\/#organization\",\"name\":\"Pfanstiehl\",\"url\":\"https:\\\/\\\/pfanstiehl.com\\\/en\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/pfanstiehl.com\\\/en\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/pfanstiehl.com\\\/wp-content\\\/uploads\\\/2024\\\/06\\\/logo.png\",\"contentUrl\":\"https:\\\/\\\/pfanstiehl.com\\\/wp-content\\\/uploads\\\/2024\\\/06\\\/logo.png\",\"width\":600,\"height\":85,\"caption\":\"Pfanstiehl\"},\"image\":{\"@id\":\"https:\\\/\\\/pfanstiehl.com\\\/en\\\/#\\\/schema\\\/logo\\\/image\\\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"L-Histidine HCl Excipient GMP BP EP JP ChP - CAS 5934-29-2 - Pfanstiehl","description":"L-Histidine HCl Excipient GMP for Highest Purity, Lowest Endotoxin, Lowest Metals amino acid for enhanced biologic formulation buffering and stability","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/pfanstiehl.com\/en\/high-purity-ingredients\/histidine-hcl\/","og_locale":"en_US","og_type":"article","og_title":"L-Histidine HCl Excipient GMP BP EP JP ChP - CAS 5934-29-2 - Pfanstiehl","og_description":"L-Histidine HCl Excipient GMP for Highest Purity, Lowest Endotoxin, Lowest Metals amino acid for enhanced biologic formulation buffering and stability","og_url":"https:\/\/pfanstiehl.com\/en\/high-purity-ingredients\/histidine-hcl\/","og_site_name":"Pfanstiehl","twitter_card":"summary_large_image","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"CollectionPage","@id":"https:\/\/pfanstiehl.com\/en\/high-purity-ingredients\/histidine-hcl\/","url":"https:\/\/pfanstiehl.com\/en\/high-purity-ingredients\/histidine-hcl\/","name":"L-Histidine HCl Excipient GMP BP EP JP ChP - CAS 5934-29-2 - Pfanstiehl","isPartOf":{"@id":"https:\/\/pfanstiehl.com\/en\/#website"},"description":"L-Histidine HCl Excipient GMP for Highest Purity, Lowest Endotoxin, Lowest Metals amino acid for enhanced biologic formulation buffering and stability","breadcrumb":{"@id":"https:\/\/pfanstiehl.com\/en\/high-purity-ingredients\/histidine-hcl\/#breadcrumb"},"inLanguage":"en-US"},{"@type":"BreadcrumbList","@id":"https:\/\/pfanstiehl.com\/en\/high-purity-ingredients\/histidine-hcl\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/pfanstiehl.com\/en\/"},{"@type":"ListItem","position":2,"name":"L-Histidine HCl"}]},{"@type":"WebSite","@id":"https:\/\/pfanstiehl.com\/en\/#website","url":"https:\/\/pfanstiehl.com\/en\/","name":"Pfanstiehl","description":"","publisher":{"@id":"https:\/\/pfanstiehl.com\/en\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/pfanstiehl.com\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/pfanstiehl.com\/en\/#organization","name":"Pfanstiehl","url":"https:\/\/pfanstiehl.com\/en\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/pfanstiehl.com\/en\/#\/schema\/logo\/image\/","url":"https:\/\/pfanstiehl.com\/wp-content\/uploads\/2024\/06\/logo.png","contentUrl":"https:\/\/pfanstiehl.com\/wp-content\/uploads\/2024\/06\/logo.png","width":600,"height":85,"caption":"Pfanstiehl"},"image":{"@id":"https:\/\/pfanstiehl.com\/en\/#\/schema\/logo\/image\/"}}]}},"_links":{"self":[{"href":"https:\/\/pfanstiehl.com\/en\/wp-json\/wp\/v2\/product_cat\/81","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pfanstiehl.com\/en\/wp-json\/wp\/v2\/product_cat"}],"about":[{"href":"https:\/\/pfanstiehl.com\/en\/wp-json\/wp\/v2\/taxonomies\/product_cat"}],"wp:post_type":[{"href":"https:\/\/pfanstiehl.com\/en\/wp-json\/wp\/v2\/product?product_cat=81"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}